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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(37
): e1472
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Clinical and Immunologic Characteristics of Patients With ANCA-Associated
Glomerulonephritis Combined With Membranous Nephropathy: A Retrospective Cohort
Study in a Single Chinese Center
#MMPMID26376387
Zou R
; Liu G
; Cui Z
; Chen M
; Zhao MH
Medicine (Baltimore)
2015[Sep]; 94
(37
): e1472
PMID26376387
show ga
The concurrent antineutrophil cytoplasmic antibody-associated glomerulonephritis
(ANCA-GN) and membranous nephropathy (MN) have been increasingly documented,
mainly in case studies and case series; however, the differences of clinical and
pathologic characteristics as well as outcomes between ANCA-GN patients with and
without MN remain unclear. The current study investigated the clinical and
immunologic features of patients with combined ANCA-GN and MN in a large cohort.
Twenty-seven of 223 patients had combined ANCA-GN and MN; they had significantly
higher levels of initial serum creatinine, higher Birmingham Vasculitis Activity
Score and poorer renal outcome than ANCA-GN patients without MN (P?0.05).
ANCA-GN patients with MN could recognize the light chain of myeloperoxidase more
frequently than those without MN (P?0.05). The prevalence of circulating
anti-PLA2R antibodies and glomerular PLA2R deposits was significantly lower in
patients with combined ANCA-GN and MN than that in patients with idiopathic MN
(P?0.05). Compared with the idiopathic MN patients, the patients with combined
ANCA-GN and MN had significantly higher recognition frequency of immunoglobulin
(Ig) G2 and IgG3, and significantly lower recognition frequency of IgG4
(P?0.05). Patients with combined ANCA-GN and MN had distinct clinical features
and a different pathogenesis of MN.