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10.1016/j.jclinepi.2015.05.024 http://scihub22266oqcxt.onion/10.1016/j.jclinepi.2015.05.024 C4635379!4635379!26186982     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Epidemiol 2015 ; 68 (11): 1325-35 Nephropedia Template TP {{tp|p=26186982|t=2015. How individual participant data meta-analyses have influenced trial design, conduct, and analysis |pdf=|usr=}}{{26186982}} gab.com Text How individual participant data meta-analyses have influenced trial design, conduct, and analysis JO: J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=26186982 #FOAvip Objectives: To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer. Study Design and Setting: Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses and knowledge of trials in their respective clinical areas. Experts in the field who did not attend were asked to provide any further examples. We then examined relevant trial protocols, publications, and Web sites to verify the impacts of the IPD meta-analyses. A subgroup of workshop attendees sought further examples and identified other aspects of trial design and conduct that may inform IPD meta-analyses. Results: We identified 52 examples of IPD meta-analyses thought to have had a direct impact on the design or conduct of trials. After screening relevant trial protocols and publications, we identified 28 instances where IPD meta-analyses had clearly impacted on trials. They have influenced the selection of comparators and participants, sample size calculations, analysis and interpretation of subsequent trials, and the conduct and analysis of ongoing trials, sometimes in ways that would not possible with systematic reviews of aggregate data. We identified additional potential ways that IPD meta-analyses could be used to influence trials. Conclusions: IPD meta-analysis could be better used to inform the design, conduct, analysis, and interpretation of trials. Twit Text FOAVip How individual participant data meta-analyses have influenced trial design, conduct, and analysis ????J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=26186982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26186982 #FOAvip English Wikipedia <ref>{{Cite pmid|26186982}}</ref> How individual participant data meta-analyses have influenced trial design, conduct, and analysis #MMPMID26186982 Tierney JF; Pignon JP; Gueffyier F; Clarke M; Askie L; Vale CL; Burdett S J Clin Epidemiol 2015[Nov]; 68 (11): 1325-35 PMID26186982show ga Objectives: To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer. Study Design and Setting: Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses and knowledge of trials in their respective clinical areas. Experts in the field who did not attend were asked to provide any further examples. We then examined relevant trial protocols, publications, and Web sites to verify the impacts of the IPD meta-analyses. A subgroup of workshop attendees sought further examples and identified other aspects of trial design and conduct that may inform IPD meta-analyses. Results: We identified 52 examples of IPD meta-analyses thought to have had a direct impact on the design or conduct of trials. After screening relevant trial protocols and publications, we identified 28 instances where IPD meta-analyses had clearly impacted on trials. They have influenced the selection of comparators and participants, sample size calculations, analysis and interpretation of subsequent trials, and the conduct and analysis of ongoing trials, sometimes in ways that would not possible with systematic reviews of aggregate data. We identified additional potential ways that IPD meta-analyses could be used to influence trials. Conclusions: IPD meta-analysis could be better used to inform the design, conduct, analysis, and interpretation of trials. äHow individual participant data meta-analyses have influenced trial de(epmc).pdf DeepDyve Pubget Overpricing