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2015 ; 7
(10
): 1749-55
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The efficacy and toxicities of combined lobaplatin with paclitaxel as a
first-line chemotherapy for advanced esophageal squamous cell carcinoma
#MMPMID26623097
Chen MQ
; Chen C
; Lu HJ
; Xu BH
J Thorac Dis
2015[Oct]; 7
(10
): 1749-55
PMID26623097
show ga
BACKGROUND: To assess the efficacy and toxicities of combined lobaplatin with
paclitaxel (LP) as a first line chemotherapy in esophageal cancer. METHODS: The
clinical data of 45 patients with esophageal squamous cell carcinoma treated
initially with lobaplatin-paclitaxel chemotherapy were collected and reviewed
retrospectively. The overall response, treatment toxicities and dysphagia relief
were analyzed with SPSS software. RESULTS: The overall response rate was 42.2%,
with 1 patient (2.2%) showing complete remission, 18 patients (40.0%) with
partial remission, 19 (42.2%) with stable disease (SD), and 7 (15.6%) with
progressive disease, respectively. The most common hematological toxicity was
leucopenia with grade 0, I, II, III and IV in 16 (35.6%), 10 (22.2%), 11 (24.4%),
7 (15.6%), and 1 patient (2.2%), respectively. Thirty-seven patients (82.2%)
experienced grade I-II nausea/vomiting without grade III-IV instances occurring.
Four patients (8.9%) experienced grade I hepatotoxicity. No nephrotoxicity was
observed. Five in thirteen patients treated with concurrent chemoradiotherapy
(CRT) suffered severe radiation pneumonitis. The dysphagia resolved or improved
in 32 patients (71%). CONCLUSIONS: Lobaplatin-paclitaxel showed a significant
antitumor effect to squamous esophageal cancer with manageable toxicities.
Limitation of the surveillance time and the retrospective nature, the effect that
based on these data formal prospective trials appear warranted and are needed
prior to routine first line use of this regimen.