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10.4254/wjh.v7.i25.2563 http://scihub22266oqcxt.onion/10.4254/wjh.v7.i25.2563 C4635141!4635141!26557948     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Hepatol 2015 ; 7 (25): 2563-70 Nephropedia Template TP {{tp|p=26557948|t=2015. Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma |pdf=|usr=}}{{26557948}} gab.com Text Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma JO: World J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26557948 #FOAvip Cholangiocarcinoma (CC) is primarily a malignant tumor of older adults most prevalent in Southeast Asia, where liver fluke infestation is high. However the etiology in western countries is unknown. Although the incidence of extrahepatic cholangiocarcinoma has remained constant, incidence of intrahepatic CC (ICC) which differs in morphology, pathogenesis, risk factors, treatment and prognosis is increasing. While this increase is associated with hepatitis C virus infection, chronic nonalcoholic liver disease, obesity, and smoking, the pathogenesis of ICC and molecular alterations underlying the carcinogenesis are not completely elucidated. Benign biliary lesions such as biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, von Meyenburg complex or bile duct hamartoma, and bile duct adenoma have been associated with ICC. For each of these entities, evidence suggests or supports a role as premalignant lesions. This article summarized the important biological significance of the precursor lesions of ICC and the molecular mechanisms that may be involved in intrahepatic cholangiocarcinogenesis. Twit Text FOAVip Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma ????World J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26557948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26557948 #FOAvip English Wikipedia <ref>{{Cite pmid|26557948}}</ref> Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma #MMPMID26557948 Ettel M; Eze O; Xu R World J Hepatol 2015[Nov]; 7 (25): 2563-70 PMID26557948show ga Cholangiocarcinoma (CC) is primarily a malignant tumor of older adults most prevalent in Southeast Asia, where liver fluke infestation is high. However the etiology in western countries is unknown. Although the incidence of extrahepatic cholangiocarcinoma has remained constant, incidence of intrahepatic CC (ICC) which differs in morphology, pathogenesis, risk factors, treatment and prognosis is increasing. While this increase is associated with hepatitis C virus infection, chronic nonalcoholic liver disease, obesity, and smoking, the pathogenesis of ICC and molecular alterations underlying the carcinogenesis are not completely elucidated. Benign biliary lesions such as biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, von Meyenburg complex or bile duct hamartoma, and bile duct adenoma have been associated with ICC. For each of these entities, evidence suggests or supports a role as premalignant lesions. This article summarized the important biological significance of the precursor lesions of ICC and the molecular mechanisms that may be involved in intrahepatic cholangiocarcinogenesis. äClinical and biological significance of precursor lesions of intrahepa(epmc).pdf DeepDyve Pubget Overpricing