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10.1111/jam.12940

http://scihub22266oqcxt.onion/10.1111/jam.12940
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C4633698!4633698!26294263
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suck abstract from ncbi


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pmid26294263      J+Appl+Microbiol 2015 ; 119 (5): 1403-11
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  • A new small molecule inhibits streptococcus mutans biofilms in vitro and in vivo #MMPMID26294263
  • Pan W; Fan M; Wu H; Melander C; Liu C
  • J Appl Microbiol 2015[Nov]; 119 (5): 1403-11 PMID26294263show ga
  • Aims: The aim of this study is to identify new small molecules that can inhibit Streptococcus mutans biofilms by in-vitro and in-vivo model. Methods and Results: We evaluated the effect of a small molecule 2-amino-imidazole/triazole conjugate (2-AI/T) on the formation of S. mutans biofilms by culturing in 96-well plates. Toxicity was assessed through cell culture and intragastrically administering to mice. The anti-biofilm and anti-caries effects were investigated in vivo. The inhibitive mechanism was detected by isobaric tag for relative and absolute quantitation (itraq) and RT-QPCR. In vitro and in vivo study revealed that 2-AI/T significantly inhibited biofilm formation of S. mutans and is more so than inhibiting planktonic cells without toxicity. The ribosome and histidine metabolism pathways of S. mutans were significantly regulated by this compound. Conclusions: These results suggest that the 2-AI/T conjugate is a potent inhibitor that can be potentially developed into a new drug to treat and prevent dental caries. Significance and Impact of the Study: This is the first study to use small molecule from marine natural products, to protect from dental cariesin vivo. It has potential broad range application in clinical caries prevention, or as a bioactive ingredient for food applications.
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