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2015 ; 2015
(ä): 846942
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NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical
Symptoms of Hepatocellular Carcinoma
#MMPMID26579207
Ji Z
; Meng G
; Huang D
; Yue X
; Wang B
Comput Math Methods Med
2015[]; 2015
(ä): 846942
PMID26579207
show ga
BACKGROUND: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy.
Traditional Chinese Medicine (TCM), with the characteristics of syndrome
differentiation, plays an important role in the comprehensive treatment of HCC.
This study aims to develop a nonnegative matrix factorization- (NMF-) based
feature selection approach (NMFBFS) to identify potential clinical symptoms for
HCC patient stratification. METHODS: The NMFBFS approach consisted of three major
steps. Firstly, statistics-based preliminary feature screening was designed to
detect and remove irrelevant symptoms. Secondly, NMF was employed to infer
redundant symptoms. Based on NMF-derived basis matrix, we defined a novel
similarity measurement of intersymptoms. Finally, we converted each group of
redundant symptoms to a new single feature so that the dimension was further
reduced. RESULTS: Based on a clinical dataset consisting of 407 patient samples
of HCC with 57 symptoms, NMFBFS approach detected 8 irrelevant symptoms and then
identified 16 redundant symptoms within 6 groups. Finally, an optimal feature
subset with 39 clinical features was generated after compressing the redundant
symptoms by groups. The validation of classification performance shows that these
39 features obviously improve the prediction accuracy of HCC patients.
CONCLUSIONS: Compared with other methods, NMFBFS has obvious advantages in
identifying important clinical features of HCC.