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10.1007/s00005-015-0348-8 http://scihub22266oqcxt.onion/10.1007/s00005-015-0348-8 C4633444!4633444!26093653     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Immunol+Ther+Exp+(Warsz) 2015 ; 63 (6): 475-83 Nephropedia Template TP {{tp|p=26093653|t=2015. Endotoxin Elimination in Patients with Septic Shock: An Observation Study |pdf=|usr=}}{{26093653}} gab.com Text Endotoxin Elimination in Patients with Septic Shock: An Observation Study JO: Arch Immunol Ther Exp (Warsz) http://www.kidney.de/pget.php?&tw=1&pmid=26093653 #FOAvip To evaluate the effectiveness of endotoxin elimination with an adsorption column in patients with septic shock and endotoxemia. The elimination therapy was guided by a new bedside method of measuring endotoxin activity (EA). Intensive care unit (ICU) patients with septic shock and suspected Gram-negative infection were consecutively added to the study group within the first 24 h. Endotoxin elimination was performed using hemoperfusion with the Alteco LPS Adsorber. The primary endpoint was improvement in organ function within the first 24 h of treatment. A secondary objective was to assess the usefulness of a new method of measuring EA to help guide endotoxin elimination therapy. Out of 64 patients 18 had a high baseline EA [0.70 EA units (0.66?0.77)]. Those patients had endotoxin elimination treatment in addition to conventional medical therapy. At 24 h after endotoxin elimination, the EA had decreased to 0.56 EA units (0.43?0.77), (p = 0.005); MAP increased from 69 (62?80) to 80 mm Hg (68?88), (p = 0.002), and noradrenaline use decreased from 0.28 (0.15?0.80) to 0.1 ?g/kg/min (0.00?0.70) at the same time (p = 0.04). The SOFA score had decreased from 11 (9?15) to 9 (7?14) points 24 h after endotoxin elimination (p = 0.01) with a median delta SOFA ?2 points. Endotoxin elimination did not have a significant effect on the ICU length of stay or ICU mortality. Effective endotoxin elimination resulted in a significant improvement in hemodynamic parameters and of organ function. The application of the EA assay was useful for the bedside monitoring of endotoxemia in critically ill ICU patients. Twit Text FOAVip Endotoxin Elimination in Patients with Septic Shock: An Observation Study ????Arch Immunol Ther Exp (Warsz) http://www.kidney.de/pget.php?&tw=1&pmid=26093653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26093653 #FOAvip English Wikipedia <ref>{{Cite pmid|26093653}}</ref> Endotoxin Elimination in Patients with Septic Shock: An Observation Study #MMPMID26093653 Adamik B; Zielinski S; Smiechowicz J; Kübler A Arch Immunol Ther Exp (Warsz) 2015[]; 63 (6): 475-83 PMID26093653show ga To evaluate the effectiveness of endotoxin elimination with an adsorption column in patients with septic shock and endotoxemia. The elimination therapy was guided by a new bedside method of measuring endotoxin activity (EA). Intensive care unit (ICU) patients with septic shock and suspected Gram-negative infection were consecutively added to the study group within the first 24 h. Endotoxin elimination was performed using hemoperfusion with the Alteco LPS Adsorber. The primary endpoint was improvement in organ function within the first 24 h of treatment. A secondary objective was to assess the usefulness of a new method of measuring EA to help guide endotoxin elimination therapy. Out of 64 patients 18 had a high baseline EA [0.70 EA units (0.66?0.77)]. Those patients had endotoxin elimination treatment in addition to conventional medical therapy. At 24 h after endotoxin elimination, the EA had decreased to 0.56 EA units (0.43?0.77), (p = 0.005); MAP increased from 69 (62?80) to 80 mm Hg (68?88), (p = 0.002), and noradrenaline use decreased from 0.28 (0.15?0.80) to 0.1 ?g/kg/min (0.00?0.70) at the same time (p = 0.04). The SOFA score had decreased from 11 (9?15) to 9 (7?14) points 24 h after endotoxin elimination (p = 0.01) with a median delta SOFA ?2 points. Endotoxin elimination did not have a significant effect on the ICU length of stay or ICU mortality. Effective endotoxin elimination resulted in a significant improvement in hemodynamic parameters and of organ function. The application of the EA assay was useful for the bedside monitoring of endotoxemia in critically ill ICU patients. äEndotoxin Elimination in Patients with Septic Shock: An Observation St(epmc).pdf DeepDyve Pubget Overpricing