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10.1101/cshperspect.a022855 http://scihub22266oqcxt.onion/10.1101/cshperspect.a022855 C4632860!4632860!26525454     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26525454&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2015 ; 5 (11): ä Nephropedia Template TP {{tp|p=26525454|t=2015. Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization |pdf=|usr=}}{{26525454}} gab.com Text Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=26525454 #FOAvip Epilepsy is a complex disorder involving neurological alterations that lead to the pathological development of spontaneous, recurrent seizures. For decades, seizures were thought to be largely repetitive, and had been examined at the macrocircuit level using electrophysiological recordings. However, research mapping the dynamics of large neuronal populations has revealed that seizures are not simply recurrent bursts of hypersynchrony. Instead, it is becoming clear that seizures involve a complex interplay of different neurons and circuits. Herein, we will review studies examining microcircuit changes that may underlie network hyperexcitability, discussing observations from network theory, computational modeling, and optogenetics. We will delve into the idea of hub cells as pathological centers for seizure activity, and will explore optogenetics as a novel avenue to target and treat pathological circuits. Finally, we will conclude with a discussion on future directions in the field. Twit Text FOAVip Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=26525454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26525454 #FOAvip English Wikipedia <ref>{{Cite pmid|26525454}}</ref> Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization #MMPMID26525454 Bui A; Kim HK; Maroso M; Soltesz I Cold Spring Harb Perspect Med 2015[Nov]; 5 (11): ä PMID26525454show ga Epilepsy is a complex disorder involving neurological alterations that lead to the pathological development of spontaneous, recurrent seizures. For decades, seizures were thought to be largely repetitive, and had been examined at the macrocircuit level using electrophysiological recordings. However, research mapping the dynamics of large neuronal populations has revealed that seizures are not simply recurrent bursts of hypersynchrony. Instead, it is becoming clear that seizures involve a complex interplay of different neurons and circuits. Herein, we will review studies examining microcircuit changes that may underlie network hyperexcitability, discussing observations from network theory, computational modeling, and optogenetics. We will delve into the idea of hub cells as pathological centers for seizure activity, and will explore optogenetics as a novel avenue to target and treat pathological circuits. Finally, we will conclude with a discussion on future directions in the field. äMicrocircuits in Epilepsy: Heterogeneity and Hub Cells in Network Sync(epmc).pdf DeepDyve Pubget Overpricing