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2015 ; 16
(10
): 25881-96
Nephropedia Template TP
gab.com Text
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Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver
and Heart in High Fat Diet-Hamsters via TGF-? Suppression
#MMPMID26516851
Ting WJ
; Kuo WW
; Hsieh DJ
; Yeh YL
; Day CH
; Chen YH
; Chen RJ
; Padma VV
; Chen YH
; Huang CY
Int J Mol Sci
2015[Oct]; 16
(10
): 25881-96
PMID26516851
show ga
Obesity is one of the major risk factors for nonalcoholic fatty liver disease
(NAFLD), and NAFLD is highly associated with an increased risk of cardiovascular
disease (CVD). Scholars have suggested that certain probiotics may significantly
impact cardiovascular health, particularly certain Lactobacillus species, such as
Lactobacillus reuteri GMNL-263 (Lr263) probiotics, which have been shown to
reduce obesity and arteriosclerosis in vivo. In the present study, we examined
the potential of heat-killed bacteria to attenuate high fat diet (HFD)-induced
hepatic and cardiac damages and the possible underlying mechanism of the positive
effects of heat-killed Lr263 oral supplements. Heat-killed Lr263 treatments (625
and 3125 mg/kg-hamster/day) were provided as a daily supplement by oral gavage to
HFD-fed hamsters for eight weeks. The results show that heat-killed Lr263
treatments reduce fatty liver syndrome. Moreover, heat-killed Lactobacillus
reuteri GMNL-263 supplementation in HFD hamsters also reduced fibrosis in the
liver and heart by reducing transforming growth factor ? (TGF-?) expression
levels. In conclusion, heat-killed Lr263 can reduce lipid metabolic stress in HFD
hamsters and decrease the risk of fatty liver and cardiovascular disease.