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10.3390/ijms161024032 http://scihub22266oqcxt.onion/10.3390/ijms161024032 C4632736!4632736 !26473838     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26473838 &cmd=llinks): Failed to open stream: HTTP request failed! 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MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3 |pdf=|usr=}}{{26473838 }} gab.com Text MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26473838 #FOAvip MicroRNAs (miRNAs) possess an important regulating effect among numerous renal diseases, while their functions in the process of epithelial-to-mesenchymal transition (EMT) after podocyte injury remain unclear. The purpose of our study is to identify the potential functions of miR-30a in EMT of podocytes and explore the underlying mechanisms of miR-30a in the impaired podocytes. The results revealed that downregulation of miR-30a in podocyte injury animal models and patients, highly induced the mesenchymal markers of EMT including Collagen I, Fibronectin and Snail. Furthermore, overexpression of miR-30a enhances epithelial markers (E-cadherin) but diminished mesenchymal markers (Collagen I, Fibronectin and Snail) in podocytes. In addition, we established miR-30a target NFATc3, an important transcription factor of Non-canonical Wnt signaling pathway. More importantly, our findings demonstrated that the augmentation of miR-30a level in podocytes inhibits the nuclear translocation of NFATc3 to protect cytoskeleton disorder or rearrangement. In summary, we uncovered the protective function of miR30a targeting NFATc3 in the regulation of podocyte injury response to EMT. Twit Text FOAVip MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26473838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26473838 #FOAvip English Wikipedia <ref>{{Cite pmid|26473838 }}</ref> MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3 #MMPMID26473838 Peng R ; Zhou L ; Zhou Y ; Zhao Y ; Li Q ; Ni D ; Hu Y ; Long Y ; Liu J ; Lyu Z ; Mao Z ; Yuan Y ; Huang L ; Zhao H ; Li G ; Zhou Q Int J Mol Sci 2015[Oct]; 16 (10 ): 24032-47 PMID26473838 show ga MicroRNAs (miRNAs) possess an important regulating effect among numerous renal diseases, while their functions in the process of epithelial-to-mesenchymal transition (EMT) after podocyte injury remain unclear. The purpose of our study is to identify the potential functions of miR-30a in EMT of podocytes and explore the underlying mechanisms of miR-30a in the impaired podocytes. The results revealed that downregulation of miR-30a in podocyte injury animal models and patients, highly induced the mesenchymal markers of EMT including Collagen I, Fibronectin and Snail. Furthermore, overexpression of miR-30a enhances epithelial markers (E-cadherin) but diminished mesenchymal markers (Collagen I, Fibronectin and Snail) in podocytes. In addition, we established miR-30a target NFATc3, an important transcription factor of Non-canonical Wnt signaling pathway. More importantly, our findings demonstrated that the augmentation of miR-30a level in podocytes inhibits the nuclear translocation of NFATc3 to protect cytoskeleton disorder or rearrangement. In summary, we uncovered the protective function of miR30a targeting NFATc3 in the regulation of podocyte injury response to EMT. |Active Transport, Cell Nucleus/genetics [MESH] |Animals [MESH] |Cadherins/biosynthesis [MESH] |Cell Line [MESH] |Collagen Type I/biosynthesis [MESH] |Down-Regulation [MESH] |Epithelial-Mesenchymal Transition/genetics/*physiology [MESH] |Fibronectins/biosynthesis [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glomerulosclerosis, Focal Segmental/pathology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |MicroRNAs/*biosynthesis/genetics [MESH] |NFATC Transcription Factors/*biosynthesis/metabolism [MESH] |Podocytes/*metabolism [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/biosynthesis [MESH]MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes t(epmc).pdf DeepDyve Pubget Overpricing