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10.3390/ijms161023143

http://scihub22266oqcxt.onion/10.3390/ijms161023143
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suck abstract from ncbi


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pmid26404236
      Int+J+Mol+Sci 2015 ; 16 (10 ): 23143-64
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  • Applications of Engineered DNA-Binding Molecules Such as TAL Proteins and the CRISPR/Cas System in Biology Research #MMPMID26404236
  • Fujita T ; Fujii H
  • Int J Mol Sci 2015[Sep]; 16 (10 ): 23143-64 PMID26404236 show ga
  • Engineered DNA-binding molecules such as transcription activator-like effector (TAL or TALE) proteins and the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) (CRISPR/Cas) system have been used extensively for genome editing in cells of various types and species. The sequence-specific DNA-binding activities of these engineered DNA-binding molecules can also be utilized for other purposes, such as transcriptional activation, transcriptional repression, chromatin modification, visualization of genomic regions, and isolation of chromatin in a locus-specific manner. In this review, we describe applications of these engineered DNA-binding molecules for biological purposes other than genome editing.
  • |*CRISPR-Cas Systems [MESH]
  • |*Gene Expression Regulation [MESH]
  • |Bacterial Proteins/genetics/metabolism [MESH]
  • |CRISPR-Associated Proteins/genetics/*metabolism [MESH]
  • |DNA-Binding Proteins/genetics/*metabolism [MESH]
  • |Protein Engineering [MESH]


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