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10.1038/ni.3247 http://scihub22266oqcxt.onion/10.1038/ni.3247 C4632529!4632529!26237550     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (9): 942-9 Nephropedia Template TP {{tp|p=26237550|t=2015. Aire controls gene expression in the thymic epithelium with ordered stochasticity |pdf=|usr=}}{{26237550}} gab.com Text Aire controls gene expression in the thymic epithelium with ordered stochasticity JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26237550 #FOAvip Aire controls immunologic tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire?s specificity, we performed single-cell RNAseq and DNA methylation analysis in Aire-sufficient and -deficient medullary epithelial cells (mTECs). Each of Aire?s target genes was induced in only a minority of mTECs, independently of DNA methylation patterns, as small inter-chromosomal gene clusters activated in concert in a proportion of mTECs. These microclusters differed between individual mice, and thus suggest an organization of the DNA or of the epigenome that results from stochastic determinism, but is bookmarked and stable through mTEC divisions, ensuring more effective presentation of self-antigens, and favoring diversity of self-tolerance between individuals. Twit Text FOAVip Aire controls gene expression in the thymic epithelium with ordered stochasticity ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26237550 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237550 #FOAvip English Wikipedia <ref>{{Cite pmid|26237550}}</ref> Aire controls gene expression in the thymic epithelium with ordered stochasticity #MMPMID26237550 Meredith M; Zemmour D; Mathis D; Benoist C Nat Immunol 2015[Sep]; 16 (9): 942-9 PMID26237550show ga Aire controls immunologic tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire?s specificity, we performed single-cell RNAseq and DNA methylation analysis in Aire-sufficient and -deficient medullary epithelial cells (mTECs). Each of Aire?s target genes was induced in only a minority of mTECs, independently of DNA methylation patterns, as small inter-chromosomal gene clusters activated in concert in a proportion of mTECs. These microclusters differed between individual mice, and thus suggest an organization of the DNA or of the epigenome that results from stochastic determinism, but is bookmarked and stable through mTEC divisions, ensuring more effective presentation of self-antigens, and favoring diversity of self-tolerance between individuals. äAire controls gene expression in the thymic epithelium with ordered st(epmc).pdf DeepDyve Pubget Overpricing