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10.3390/v7102874 http://scihub22266oqcxt.onion/10.3390/v7102874 C4632382!4632382 !26473912     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26473912 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection |pdf=|usr=}}{{26473912 }} gab.com Text The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=26473912 #FOAvip Replication of the poliovirus genome is localized to cytoplasmic replication factories that are fashioned out of a mixture of viral proteins, scavenged cellular components, and new components that are synthesized within the cell due to viral manipulation/up-regulation of protein and phospholipid synthesis. These membranous replication factories are quite complex, and include markers from multiple cytoplasmic cellular organelles. This review focuses on the role of electron microscopy in advancing our understanding of poliovirus RNA replication factories. Structural data from the literature provide the basis for interpreting a wide range of biochemical studies that have been published on virus-induced lipid biosynthesis. In combination, structural and biochemical experiments elucidate the dramatic membrane remodeling that is a hallmark of poliovirus infection. Temporal and spatial membrane modifications throughout the infection cycle are discussed. Early electron microscopy studies of morphological changes following viral infection are re-considered in light of more recent data on viral manipulation of lipid and protein biosynthesis. These data suggest the existence of distinct subcellular vesicle populations, each of which serves specialized roles in poliovirus replication processes. Twit Text FOAVip The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=26473912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26473912 #FOAvip English Wikipedia <ref>{{Cite pmid|26473912 }}</ref> The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection #MMPMID26473912 Rossignol ED ; Yang JE ; Bullitt E Viruses 2015[Oct]; 7 (10 ): 5305-18 PMID26473912 show ga Replication of the poliovirus genome is localized to cytoplasmic replication factories that are fashioned out of a mixture of viral proteins, scavenged cellular components, and new components that are synthesized within the cell due to viral manipulation/up-regulation of protein and phospholipid synthesis. These membranous replication factories are quite complex, and include markers from multiple cytoplasmic cellular organelles. This review focuses on the role of electron microscopy in advancing our understanding of poliovirus RNA replication factories. Structural data from the literature provide the basis for interpreting a wide range of biochemical studies that have been published on virus-induced lipid biosynthesis. In combination, structural and biochemical experiments elucidate the dramatic membrane remodeling that is a hallmark of poliovirus infection. Temporal and spatial membrane modifications throughout the infection cycle are discussed. Early electron microscopy studies of morphological changes following viral infection are re-considered in light of more recent data on viral manipulation of lipid and protein biosynthesis. These data suggest the existence of distinct subcellular vesicle populations, each of which serves specialized roles in poliovirus replication processes. |*Lipid Metabolism [MESH] |*Virus Replication [MESH] |Cytoplasmic Vesicles/*ultrastructure/*virology [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Microscopy, Electron/*methods [MESH]The Role of Electron Microscopy in Studying the Continuum of Changes i(epmc).pdf DeepDyve Pubget Overpricing