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10.1038/cddis.2015.273 http://scihub22266oqcxt.onion/10.1038/cddis.2015.273 C4632301!4632301 !26448322     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26448322 &cmd=llinks): Failed to open stream: HTTP request failed! 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Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation |pdf=|usr=}}{{26448322 }} gab.com Text Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26448322 #FOAvip Primary cilia are antenna-like structures projected from the apical surface of various mammalian cells including renal tubular cells. Functional or structural defects of the cilium lead to systemic disorders comprising polycystic kidneys as a key feature. Here we show that anoctamin 6 (ANO6), a member of the anoctamin chloride channel family, is localized in the primary cilium of renal epithelial cells in vitro and in vivo. ANO6 was not essential for cilia formation and had no effect on in vitro cyst expansion. However, knockdown of ANO6 impaired cyst lumen formation of MDCK cells in three-dimensional culture. In the absence of ANO6, apoptosis was reduced and epithelial cells were incompletely removed from the center of cell aggregates, which form in the early phase of cystogenesis. In line with these data, we show that ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. These data identify ANO6 as a cilium-associated protein and suggest its functional relevance in cyst formation. Twit Text FOAVip Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26448322 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26448322 #FOAvip English Wikipedia <ref>{{Cite pmid|26448322 }}</ref> Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation #MMPMID26448322 Forschbach V ; Goppelt-Struebe M ; Kunzelmann K ; Schreiber R ; Piedagnel R ; Kraus A ; Eckardt KU ; Buchholz B Cell Death Dis 2015[Oct]; 6 (10 ): e1899 PMID26448322 show ga Primary cilia are antenna-like structures projected from the apical surface of various mammalian cells including renal tubular cells. Functional or structural defects of the cilium lead to systemic disorders comprising polycystic kidneys as a key feature. Here we show that anoctamin 6 (ANO6), a member of the anoctamin chloride channel family, is localized in the primary cilium of renal epithelial cells in vitro and in vivo. ANO6 was not essential for cilia formation and had no effect on in vitro cyst expansion. However, knockdown of ANO6 impaired cyst lumen formation of MDCK cells in three-dimensional culture. In the absence of ANO6, apoptosis was reduced and epithelial cells were incompletely removed from the center of cell aggregates, which form in the early phase of cystogenesis. In line with these data, we show that ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. These data identify ANO6 as a cilium-associated protein and suggest its functional relevance in cyst formation. |*Apoptosis [MESH] |Anoctamins [MESH] |Cell Membrane/metabolism [MESH] |Cells, Cultured [MESH] |Cilia/*metabolism [MESH] |Humans [MESH] |Kidney Tubules/metabolism/pathology [MESH] |Phospholipid Transfer Proteins/*metabolism [MESH] |Phospholipids/metabolism [MESH] |Polycystic Kidney Diseases/*metabolism [MESH]Anoctamin 6 is localized in the primary cilium of renal tubular cells (epmc).pdf DeepDyve Pubget Overpricing