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10.1038/cddis.2015.269 http://scihub22266oqcxt.onion/10.1038/cddis.2015.269 C4632298!4632298 !26469956     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26469956 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer |pdf=|usr=}}{{26469956 }} gab.com Text Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26469956 #FOAvip The level of microRNA-205 (miR-205) is commonly deregulated in a number of cancers. Through the screening of the microRNA expression profile in bladder cancer tissue and cell lines, we found that expression of miR-205 was significantly suppressed. In addition, the levels of miR-205 expression had a negative correlation with the degree of bladder cancer malignancy. However, the biological functions of miR-205 remained unclear. In this study, we have demonstrated that miR-205 had a role in the inhibition of proliferation, migration and invasion of bladder cancer cells. Moreover, we have identified cyclin J (CCNJ) gene, which is involved in cell cycle regulation, as a novel target for miR-205. Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter. This study elucidates an important role that miR-205 had in the regulation of proliferation, migration and invasion of bladder cancer cells, suggesting a potential therapeutic target for combating bladder cancer. Twit Text FOAVip Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26469956 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26469956 #FOAvip English Wikipedia <ref>{{Cite pmid|26469956 }}</ref> Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer #MMPMID26469956 Sun X ; Du P ; Yuan W ; Du Z ; Yu M ; Yu X ; Hu T Cell Death Dis 2015[Oct]; 6 (10 ): e1907 PMID26469956 show ga The level of microRNA-205 (miR-205) is commonly deregulated in a number of cancers. Through the screening of the microRNA expression profile in bladder cancer tissue and cell lines, we found that expression of miR-205 was significantly suppressed. In addition, the levels of miR-205 expression had a negative correlation with the degree of bladder cancer malignancy. However, the biological functions of miR-205 remained unclear. In this study, we have demonstrated that miR-205 had a role in the inhibition of proliferation, migration and invasion of bladder cancer cells. Moreover, we have identified cyclin J (CCNJ) gene, which is involved in cell cycle regulation, as a novel target for miR-205. Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter. This study elucidates an important role that miR-205 had in the regulation of proliferation, migration and invasion of bladder cancer cells, suggesting a potential therapeutic target for combating bladder cancer. |*Gene Expression Regulation, Neoplastic [MESH] |3' Untranslated Regions [MESH] |Animals [MESH] |Base Sequence [MESH] |Binding Sites [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cyclins/genetics/*metabolism [MESH] |Gene Expression [MESH] |Humans [MESH] |Mice, SCID [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Transplantation [MESH] |RNA, Long Noncoding/*physiology [MESH]Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microR(epmc).pdf DeepDyve Pubget Overpricing