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10.1189/jlb.2A0913-487R http://scihub22266oqcxt.onion/10.1189/jlb.2A0913-487R C4632169!4632169 !24812060     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24812060 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Leukoc+Biol 2014 ; 96 (3 ): 427-36 Nephropedia Template TP {{tp|p=24812060 |t=2014. The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 |pdf=|usr=}}{{24812060 }} gab.com Text The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24812060 #FOAvip TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We have identified a putative TRAF6-binding motif in TRAM that could mediate a novel signaling function for TRAM in TLR4 signaling. TRAM and TRAF6 association was confirmed by immunoprecipitation of endogenous, ectopically expressed and recombinant proteins, which was ablated upon mutation of a key Glu residue in TRAM (TRAM E183A). TRAF6 and TRAM were observed colocalizing using confocal microscopy following ectopic expression in cells and the ability of TRAM and TRAM E183A to activate luciferase-linked reporter assays was determined in HEK293 and TRAF6-deficient cells. Importantly, TRAM-deficient macrophages reconstituted with TRAM E183A display significantly reduced inflammatory TNF-?, IL-6, and RANTES protein production compared with WT TRAM. These results demonstrate a novel role for TRAM in TLR4-mediated signaling in regulating inflammatory responses via its interaction with TRAF6, distinct from its role as a bridging adaptor between TLR4 and TRIF. Twit Text FOAVip The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24812060 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24812060 #FOAvip English Wikipedia <ref>{{Cite pmid|24812060 }}</ref> The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 #MMPMID24812060 Verstak B ; Stack J ; Ve T ; Mangan M ; Hjerrild K ; Jeon J ; Stahl R ; Latz E ; Gay N ; Kobe B ; Bowie AG ; Mansell A J Leukoc Biol 2014[Sep]; 96 (3 ): 427-36 PMID24812060 show ga TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We have identified a putative TRAF6-binding motif in TRAM that could mediate a novel signaling function for TRAM in TLR4 signaling. TRAM and TRAF6 association was confirmed by immunoprecipitation of endogenous, ectopically expressed and recombinant proteins, which was ablated upon mutation of a key Glu residue in TRAM (TRAM E183A). TRAF6 and TRAM were observed colocalizing using confocal microscopy following ectopic expression in cells and the ability of TRAM and TRAM E183A to activate luciferase-linked reporter assays was determined in HEK293 and TRAF6-deficient cells. Importantly, TRAM-deficient macrophages reconstituted with TRAM E183A display significantly reduced inflammatory TNF-?, IL-6, and RANTES protein production compared with WT TRAM. These results demonstrate a novel role for TRAM in TLR4-mediated signaling in regulating inflammatory responses via its interaction with TRAF6, distinct from its role as a bridging adaptor between TLR4 and TRIF. |Adaptor Proteins, Signal Transducing/chemistry/genetics/*physiology [MESH] |Adaptor Proteins, Vesicular Transport/antagonists & inhibitors/genetics [MESH] |Amino Acid Motifs [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Cytokines/biosynthesis [MESH] |Fibroblasts [MESH] |Genes, Reporter [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunoprecipitation [MESH] |Inflammation/*physiopathology [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophages/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Microscopy, Confocal [MESH] |Mutation, Missense [MESH] |Peptide Fragments/genetics/metabolism [MESH] |Point Mutation [MESH] |Protein Interaction Mapping [MESH] |RNA, Small Interfering/pharmacology [MESH] |Receptors, Interleukin/deficiency [MESH] |Recombinant Fusion Proteins/metabolism [MESH] |Signal Transduction/physiology [MESH] |TNF Receptor-Associated Factor 6/chemistry/deficiency/genetics/*physiology [MESH]The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activat(epmc).pdf DeepDyve Pubget Overpricing