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10.1189/jlb.3HI0613-340RR http://scihub22266oqcxt.onion/10.1189/jlb.3HI0613-340RR C4632164!4632164 !24696357     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24696357 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Leukoc+Biol 2014 ; 96 (3 ): 377-89 Nephropedia Template TP {{tp|p=24696357 |t=2014. Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation |pdf=|usr=}}{{24696357 }} gab.com Text Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24696357 #FOAvip Chronic colitis is accompanied by extensive myelopoiesis and accumulation of CD11b+Gr-1+ cells in spleens and secondary lymphoid tissues. Although cells with similar phenotype have been described in cancer, chronic infection, or autoimmunity, where they were associated with suppression of T cell responses, little is known regarding how these cells affect CD4 T cell responses in the context of chronic intestinal inflammation. Therefore, we undertook this study to characterize the interplay between colitis-induced myeloid cells and CD4 T cell. Within the CD11b+Gr-1+ population, only monocytes (Ly6G(neg)Ly6C(high)) but not other myeloid cell subsets suppressed proliferation and production of cytokines by CD4 T cells. Suppression was mediated by cell-contact, NO and partially by IFN-? and PGs. Interestingly, Ly6C(high) MDCs, isolated from colitic colons, showed up-regulation of iNOS and arginase-1 and were more potent suppressors than those isolated from spleen. On a single-cell level, MDCs inhibited Th1 responses but enhanced generation of foxp3+ T cells. MDCs, cocultured with activated/Teffs, isolated from inflamed colons under hypoxic (1% O2) conditions typical for the inflamed intestine, suppressed proliferation but not their production of proinflammatory cytokines and chemokines. Taken together, expansion of monocytes and MDCs and activation of their suppressive properties may represent a homeostatic mechanism aimed at restraining excessive T cell activation during chronic inflammatory settings. The contribution of immunosuppressive monocytes/MDCs to chronic colitis and their role in shaping T cell responses in vivo require further investigation. Twit Text FOAVip Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24696357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24696357 #FOAvip English Wikipedia <ref>{{Cite pmid|24696357 }}</ref> Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation #MMPMID24696357 Kurmaeva E ; Bhattacharya D ; Goodman W ; Omenetti S ; Merendino A ; Berney S ; Pizarro T ; Ostanin DV J Leukoc Biol 2014[Sep]; 96 (3 ): 377-89 PMID24696357 show ga Chronic colitis is accompanied by extensive myelopoiesis and accumulation of CD11b+Gr-1+ cells in spleens and secondary lymphoid tissues. Although cells with similar phenotype have been described in cancer, chronic infection, or autoimmunity, where they were associated with suppression of T cell responses, little is known regarding how these cells affect CD4 T cell responses in the context of chronic intestinal inflammation. Therefore, we undertook this study to characterize the interplay between colitis-induced myeloid cells and CD4 T cell. Within the CD11b+Gr-1+ population, only monocytes (Ly6G(neg)Ly6C(high)) but not other myeloid cell subsets suppressed proliferation and production of cytokines by CD4 T cells. Suppression was mediated by cell-contact, NO and partially by IFN-? and PGs. Interestingly, Ly6C(high) MDCs, isolated from colitic colons, showed up-regulation of iNOS and arginase-1 and were more potent suppressors than those isolated from spleen. On a single-cell level, MDCs inhibited Th1 responses but enhanced generation of foxp3+ T cells. MDCs, cocultured with activated/Teffs, isolated from inflamed colons under hypoxic (1% O2) conditions typical for the inflamed intestine, suppressed proliferation but not their production of proinflammatory cytokines and chemokines. Taken together, expansion of monocytes and MDCs and activation of their suppressive properties may represent a homeostatic mechanism aimed at restraining excessive T cell activation during chronic inflammatory settings. The contribution of immunosuppressive monocytes/MDCs to chronic colitis and their role in shaping T cell responses in vivo require further investigation. |Adoptive Transfer/adverse effects [MESH] |Animals [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Chemotaxis, Leukocyte [MESH] |Chronic Disease [MESH] |Colitis/blood/etiology/*immunology/pathology [MESH] |Cytokines/biosynthesis [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Genes, RAG-1 [MESH] |Homeostasis [MESH] |Immunophenotyping [MESH] |Lymphocyte Activation [MESH] |Lymphoid Tissue/immunology/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Monocytes/classification/*immunology [MESH]Immunosuppressive monocytes: possible homeostatic mechanism to restrai(epmc).pdf DeepDyve Pubget Overpricing