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Transforming growth factor-?: an important mediator in Helicobacter pylori-associated pathogenesis #MMPMID26583078
Li N; Xie C; Lu NH
Front Cell Infect Microbiol 2015[]; 5 (ä): ä PMID26583078show ga
Helicobacter pylori (H.pylori) is a Gram-negative, microaerophilic, helical bacillus that specifically colonizes the gastric mucosa. The interaction of virulence factors, host genetic factors, and environmental factors contributes to the pathogenesis of H. pylori-associated conditions, such as atrophic gastritis and intestinal metaplasia. Infection with H. pylori has recently been recognized as the strongest risk factor for gastric cancer. As a pleiotropic cytokine, transforming growth factor (TGF)-? regulates various biological processes, including cell cycle, proliferation, apoptosis, and metastasis. Recent studies have shed new light on the involvement of TGF-? signaling in the pathogenesis of H. pylori infection. This review focuses on the potential etiological roles of TGF-? in H. pylori-mediated gastric pathogenesis.