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10.1038/emi.2015.61 http://scihub22266oqcxt.onion/10.1038/emi.2015.61 C4631929!4631929 !26576339     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26576339 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Emerg+Microbes+Infect 2015 ; 4 (10 ): e61 Nephropedia Template TP {{tp|p=26576339 |t=2015. Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex |pdf=|usr=}}{{26576339 }} gab.com Text Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=26576339 #FOAvip Chikungunya virus (CHIKV) is a re-emerging alphavirus which causes severe and prolonged arthralgic febrile illness. The recent global spread of the virus and lack of approved therapeutic options makes it imperative to gain greater insight into the molecular mechanisms underlying CHIKV pathogenesis, in particular host factors recruited by the virus. In the current study, we identify sphingosine kinase 2 (SK2) as a CHIKV host factor co-localized with the viral replication complex (VRC) during infection. SK2 was demonstrated to co-localize with viral RNA and nonstructural proteins. Targeted impairment of SK2 expression or function significantly inhibited CHIKV infection. Furthermore, affinity purification-mass spectrometry studies revealed that SK2 associates with a number of proteins involved in cellular gene expression specifically during viral infection, suggesting a role in replication. Collectively these results identify SK2 as a novel CHIKV host factor. Twit Text FOAVip Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=26576339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26576339 #FOAvip English Wikipedia <ref>{{Cite pmid|26576339 }}</ref> Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex #MMPMID26576339 Reid SP ; Tritsch SR ; Kota K ; Chiang CY ; Dong L ; Kenny T ; Brueggemann EE ; Ward MD ; Cazares LH ; Bavari S Emerg Microbes Infect 2015[Oct]; 4 (10 ): e61 PMID26576339 show ga Chikungunya virus (CHIKV) is a re-emerging alphavirus which causes severe and prolonged arthralgic febrile illness. The recent global spread of the virus and lack of approved therapeutic options makes it imperative to gain greater insight into the molecular mechanisms underlying CHIKV pathogenesis, in particular host factors recruited by the virus. In the current study, we identify sphingosine kinase 2 (SK2) as a CHIKV host factor co-localized with the viral replication complex (VRC) during infection. SK2 was demonstrated to co-localize with viral RNA and nonstructural proteins. Targeted impairment of SK2 expression or function significantly inhibited CHIKV infection. Furthermore, affinity purification-mass spectrometry studies revealed that SK2 associates with a number of proteins involved in cellular gene expression specifically during viral infection, suggesting a role in replication. Collectively these results identify SK2 as a novel CHIKV host factor. |Alphavirus Infections/prevention & control/*virology [MESH] |Animals [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Chikungunya virus/*enzymology/genetics [MESH] |Gene Expression Regulation, Enzymologic [MESH] |Gene Expression Regulation, Viral [MESH] |Gene Knockdown Techniques [MESH] |HeLa Cells [MESH] |Humans [MESH] |Muscle, Skeletal/cytology [MESH] |Phosphotransferases (Alcohol Group Acceptor)/genetics/*metabolism [MESH] |RNA Interference [MESH] |RNA, Viral/metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Viral Nonstructural Proteins/metabolism [MESH]Sphingosine kinase 2 is a chikungunya virus host factor co-localized w(epmc).pdf DeepDyve Pubget Overpricing