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2015 ; 9
(ä): 581
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English Wikipedia
Aspirin in the 21st century-common mechanisms of disease and their modulation by
aspirin: a report from the 2015 scientific conference of the international
aspirin foundation, 28 August, London, UK
#MMPMID26557879
Smith T
; Hutchison P
; Schrör K
; Clària J
; Lanas A
; Patrignani P
; Chan AT
; Din F
; Langley R
; Elwood P
; Freedman A
; Eccles R
Ecancermedicalscience
2015[]; 9
(ä): 581
PMID26557879
show ga
Professor Peter Rothwell of Oxford University chaired the annual Scientific
Conference of the International Aspirin Foundation in London on 28 August 2015.
It took the form of four sessions. Aspirin has more than one action in its
effects on disease. Its acetylation of cyclooxygenase 2 (COX-2) in platelets
leads to the blockade of pro-inflammatory chemicals and generation of
anti-inflammatory mediators and increase in nitrous oxide (NO) production, which
helps to preserve arterial endothelium. But platelets are not its only target.
There is now evidence that aspirin has a direct antitumour effect on intestinal
mucosal cells that block their potential transformation into cancer cells.
Randomised placebo-controlled trials (RCTs) in people with histories of
colorectal neoplasia have shown that aspirin reduces the risk of recurrent
adenomas and reduces long-term cancer incidence in patients with Lynch syndrome.
Among women given aspirin for cardiovascular disease, there were fewer cancers
than in those given placebo. Epidemiological evidence has suggested that aspirin
treatment after cancer is diagnosed reduces the incidence of metastases and
prolongs survival, and long-term studies of anticancer treatment with aspirin are
under way to confirm this. Apart from cancer studies, aspirin use is now firmly
established as treatment for antiphospholipid syndrome (Hughes syndrome) and is
being used to prevent and treat the heightened risk of cardiovascular disease in
diabetes mellitus and in patients with HIV.