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10.1038/srep16017 http://scihub22266oqcxt.onion/10.1038/srep16017 C4630618!4630618 !26526154     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26526154 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 16017 Nephropedia Template TP {{tp|p=26526154 |t=2015. Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands |pdf=|usr=}}{{26526154 }} gab.com Text Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26526154 #FOAvip In separate studies, an extract of soluble intracellular contents from whole bone marrow cells, named "Bone Marrow (BM) Soup", was reported to either improve cardiac or salivary functions post-myocardial infarction or irradiation (IR), respectively. However, the active components in BM Soup are unknown. To demonstrate that proteins were the active ingredients, we devised a method using proteinase K followed by heating to deactivate proteins and for safe injections into mice. BM Soup and "deactivated BM Soup" were injected into mice that had their salivary glands injured with 15Gy IR. Control mice received either injections of saline or were not IR. Results at week 8 post-IR showed the 'deactivated BM Soup' was no better than injections of saline, while injections of native BM Soup restored saliva flow, protected salivary cells and blood vessels from IR-damage. Protein arrays detected several angiogenesis-related factors (CD26, FGF, HGF, MMP-8, MMP-9, OPN, PF4, SDF-1) and cytokines (IL-1ra, IL-16) in BM Soup. In conclusion, the native proteins (but not the nucleic acids, lipids or carbohydrates) were the therapeutic ingredients in BM Soup for functional salivary restoration following IR. This molecular therapy approach has clinical potential because it is theoretically less tumorigenic and immunogenic than cell therapies. Twit Text FOAVip Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26526154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26526154 #FOAvip English Wikipedia <ref>{{Cite pmid|26526154 }}</ref> Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands #MMPMID26526154 Fang D ; Hu S ; Liu Y ; Quan VH ; Seuntjens J ; Tran SD Sci Rep 2015[Nov]; 5 (ä): 16017 PMID26526154 show ga In separate studies, an extract of soluble intracellular contents from whole bone marrow cells, named "Bone Marrow (BM) Soup", was reported to either improve cardiac or salivary functions post-myocardial infarction or irradiation (IR), respectively. However, the active components in BM Soup are unknown. To demonstrate that proteins were the active ingredients, we devised a method using proteinase K followed by heating to deactivate proteins and for safe injections into mice. BM Soup and "deactivated BM Soup" were injected into mice that had their salivary glands injured with 15Gy IR. Control mice received either injections of saline or were not IR. Results at week 8 post-IR showed the 'deactivated BM Soup' was no better than injections of saline, while injections of native BM Soup restored saliva flow, protected salivary cells and blood vessels from IR-damage. Protein arrays detected several angiogenesis-related factors (CD26, FGF, HGF, MMP-8, MMP-9, OPN, PF4, SDF-1) and cytokines (IL-1ra, IL-16) in BM Soup. In conclusion, the native proteins (but not the nucleic acids, lipids or carbohydrates) were the therapeutic ingredients in BM Soup for functional salivary restoration following IR. This molecular therapy approach has clinical potential because it is theoretically less tumorigenic and immunogenic than cell therapies. |Acinar Cells/cytology/metabolism [MESH] |Animals [MESH] |Blood Vessels/drug effects/physiology [MESH] |Bone Marrow Cells/cytology/*metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Culture Media, Conditioned/pharmacology [MESH] |Cytokines/metabolism [MESH] |Endopeptidase K/metabolism [MESH] |Female [MESH] |Gamma Rays [MESH] |Intercellular Signaling Peptides and Proteins/metabolism [MESH] |Mice [MESH] |Mice, Inbred C3H [MESH] |Protein Array Analysis [MESH] |Saliva/drug effects/metabolism [MESH] |Salivary Glands/injuries/*metabolism/pathology [MESH] |Temperature [MESH]Identification of the active components in Bone Marrow Soup: a mitigat(epmc).pdf DeepDyve Pubget Overpricing