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2015 ; 2015
(ä): 798478
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Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and
Fentanyl in Synchronized Cardioversion
#MMPMID26576298
Masoumi K
; Forouzan A
; Saghari S
; Feli M
; Sattari AR
; Asgari Darian A
Crit Care Res Pract
2015[]; 2015
(ä): 798478
PMID26576298
show ga
The purpose of this study was to determine if the Entonox gas could cause
adequate analgesic and sedative effects in patients who need cardioversion. In
this randomized not blinded clinical trial, the sedative and analgesic effects of
midazolam and fentanyl were compared with Entonox. Eligible patients who need
synchronized cardioversion because of dysrhythmia were randomly divided into two
groups. The first group received intravenous midazolam and fentanyl; the second
group received Entonox through a blower-dependent mask. Onset and end of
sedation, sedation level, and pain score were recorded. There were nonsignificant
differences between the two groups (22 patients in each group) regarding age,
gender, weight, sedation level, and frequency and level of shock. The pain score
recorded in the first group was 5.05 ± 1.32, and 3.9 ± 0.7 in the second group (P
= 0.002). Furthermore, sedation duration and time to full recovery consciousness
were shorter in the second group (P < 0.001). In the first group, seven patients
needed additional doses to induce and maintain sedation. In addition, as a result
of apnoea, four patients required airway support. None of them occurred in the
second group. Entonox is a suitable medication in rapid cardioversion, as it has
minimal side effects and adequate analgesic and sedative effects.