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10.1155/2015/249740 http://scihub22266oqcxt.onion/10.1155/2015/249740 C4630372!4630372 !26576418     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26576418 &cmd=llinks): Failed to open stream: HTTP request failed! 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Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy |pdf=|usr=}}{{26576418 }} gab.com Text Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26576418 #FOAvip Since the identification of PLA2R (M-type phospholipase A2 receptor) as the first human antigenic target in primary membranous nephropathy (MN), perpetual progress has been made in understanding the pathogenesis of this disease. Accumulating clinical data support a pathogenic role for the anti-PLA2R antibodies (PLA2R ABs), but confirmation in an animal model is still lacking. However, PLA2R ABs were related to disease activity and outcome, as well as to response therapy. Accordingly, PLA2R ABs assay seems to be promising tool not only to diagnose MN but also to predict the course of the disease and could open the way to personalize therapy. Nevertheless, validation of a universal assay with high precision and definition of cut-off levels, followed by larger studies with a prolonged follow-up period, are needed to confirm these prospects. Twit Text FOAVip Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26576418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26576418 #FOAvip English Wikipedia <ref>{{Cite pmid|26576418 }}</ref> Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy #MMPMID26576418 Obrisca B ; Ismail G ; Jurubita R ; Baston C ; Andronesi A ; Mircescu G Biomed Res Int 2015[]; 2015 (ä): 249740 PMID26576418 show ga Since the identification of PLA2R (M-type phospholipase A2 receptor) as the first human antigenic target in primary membranous nephropathy (MN), perpetual progress has been made in understanding the pathogenesis of this disease. Accumulating clinical data support a pathogenic role for the anti-PLA2R antibodies (PLA2R ABs), but confirmation in an animal model is still lacking. However, PLA2R ABs were related to disease activity and outcome, as well as to response therapy. Accordingly, PLA2R ABs assay seems to be promising tool not only to diagnose MN but also to predict the course of the disease and could open the way to personalize therapy. Nevertheless, validation of a universal assay with high precision and definition of cut-off levels, followed by larger studies with a prolonged follow-up period, are needed to confirm these prospects. |Animals [MESH] |Antibodies, Monoclonal/*immunology [MESH] |Autoantibodies/*immunology [MESH] |Evidence-Based Medicine [MESH] |Glomerulonephritis, Membranous/*drug therapy/*immunology [MESH] |Humans [MESH] |Molecular Targeted Therapy/methods [MESH]Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Ma(epmc).pdf DeepDyve Pubget Overpricing