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10.1039/c5ib00207a http://scihub22266oqcxt.onion/10.1039/c5ib00207a C4630156!4630156!26379187     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Integr+Biol+(Camb) 2015 ; 7 (11): 1432-41 Nephropedia Template TP {{tp|p=26379187|t=2015. Endothelial Cell Sensing, Restructuring, and Invasion in Collagen Hydrogel Structures |pdf=|usr=}}{{26379187}} gab.com Text Endothelial Cell Sensing, Restructuring, and Invasion in Collagen Hydrogel Structures JO: Integr Biol (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=26379187 #FOAvip Experimental tools to model cell-tissue interactions will likely lead the way to new ways to both understand and treat cancer. While the mechanical properties and regulation of invasion have been recently studied for tumor cells, these have received less attention in the context of tumor vascular dynamics. In this article, we have investigated the interaction between the surfaces of structures encountered by endothelial cells invading their surrounding extracellular matrix (ECM) during angiogenesis. For this purpose, we have fabricated round and sharp geometries with various curvature and sharpness indices in collagen hydrogel at a wide range of stiffness to mimic different microenvironments varying from normal to tumor tissues. We have then cultured endothelial cells on these structures to investigate the bi-directional interaction between the cells and ECM. We have observed that cell invasion frequency is higher from the structures with the highest sharpness and curvature index, while interestingly the dependence of invasion on local micro-geometry is strongest for the highest density matrices. Notably, structures with the highest invasion length are linked with higher deformation of side structures, which may be related to traction force-activated signaling suggesting further investigation. We have noted that round structures are more favorable for cell adhesion and in some cases round structures drive cell invasion faster than sharp ones. These results highlight the ability of endothelial cells to sense small variations in ECM geometry, and to respond with a balance of matrix invasion as well as deformation, with potential implications for feedback mechanisms that may enhance vascular abnormality in response to tumor-induced ECM alterations. Twit Text FOAVip Endothelial Cell Sensing, Restructuring, and Invasion in Collagen Hydrogel Structures ????Integr Biol (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=26379187 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26379187 #FOAvip English Wikipedia <ref>{{Cite pmid|26379187}}</ref> Endothelial Cell Sensing, Restructuring, and Invasion in Collagen Hydrogel Structures #MMPMID26379187 Hosseini Y; Agah M; Verbridge S Integr Biol (Camb) 2015[Nov]; 7 (11): 1432-41 PMID26379187show ga Experimental tools to model cell-tissue interactions will likely lead the way to new ways to both understand and treat cancer. While the mechanical properties and regulation of invasion have been recently studied for tumor cells, these have received less attention in the context of tumor vascular dynamics. In this article, we have investigated the interaction between the surfaces of structures encountered by endothelial cells invading their surrounding extracellular matrix (ECM) during angiogenesis. For this purpose, we have fabricated round and sharp geometries with various curvature and sharpness indices in collagen hydrogel at a wide range of stiffness to mimic different microenvironments varying from normal to tumor tissues. We have then cultured endothelial cells on these structures to investigate the bi-directional interaction between the cells and ECM. We have observed that cell invasion frequency is higher from the structures with the highest sharpness and curvature index, while interestingly the dependence of invasion on local micro-geometry is strongest for the highest density matrices. Notably, structures with the highest invasion length are linked with higher deformation of side structures, which may be related to traction force-activated signaling suggesting further investigation. We have noted that round structures are more favorable for cell adhesion and in some cases round structures drive cell invasion faster than sharp ones. These results highlight the ability of endothelial cells to sense small variations in ECM geometry, and to respond with a balance of matrix invasion as well as deformation, with potential implications for feedback mechanisms that may enhance vascular abnormality in response to tumor-induced ECM alterations. äEndothelial Cell Sensing, Restructuring, and Invasion in Collagen Hydr(epmc).pdf DeepDyve Pubget Overpricing