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10.3349/ymj.2015.56.6.1503 http://scihub22266oqcxt.onion/10.3349/ymj.2015.56.6.1503 C4630036!4630036!26446630     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Yonsei+Med+J 2015 ; 56 (6): 1503-14 Nephropedia Template TP {{tp|p=26446630|t=2015. Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1? |pdf=|usr=}}{{26446630}} gab.com Text Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1 JO: Yonsei Med J http://www.kidney.de/pget.php?&tw=1&pmid=26446630 #FOAvip Purpose: Although follicular thyroid cancer (FTC) has a relatively fair prognosis, distant metastasis sometimes results in poor prognosis and survival. There is little understanding of the mechanisms contributing to the aggressiveness potential of thyroid cancer. We showed that hypoxia inducible factor-1? (HIF-1?) induced aggressiveness in FTC cells and identified the underlying mechanism of the HIF-1?-induced invasive characteristics. Materials and Methods: Cells were cultured under controlled hypoxic environments (1% O2) or normoxic conditions. The effect of hypoxia on HIF-1?, and epithelial-to-mesenchymal transition (EMT) related markers were evaluated by quantitative real-time PCR, Western blot analysis and immunocytochemistry. Invasion and wound healing assay were conducted to identify functional character of EMT. The involvement of HIF-1? and Twist in EMT were studied using gene overexpression or silencing. After orthotopic nude mouse model was established using the cells transfected with lentiviral shHIF-1?, tissue analysis was done. Results: Hypoxia induces HIF-1? expression and EMT, including typical morphologic changes, cadherin shift, and increased vimentin expression. We showed that overexpression of HIF-1? via transfection resulted in the aforementioned changes without hypoxia, and repression of HIF-1? with RNA interference suppressed hypoxia-induced HIF-1? and EMT. Furthermore, we also observed that Twist expression was regulated by HIF-1?. These were confirmed in the orthotopic FTC model. Conclusion: Hypoxia induced HIF-1?, which in turn induced EMT, resulting in the increased capacity for invasion and migration of cells via regulation of the Twist signal pathway in FTC cells. These findings provide insight into a possible therapeutic strategy to prevent invasive and metastatic FTC. Twit Text FOAVip Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1 ????Yonsei Med J http://www.kidney.de/pget.php?&tw=1&pmid=26446630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26446630 #FOAvip English Wikipedia <ref>{{Cite pmid|26446630}}</ref> Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1? #MMPMID26446630 Yang YJ; Na HJ; Suh MJ; Ban MJ; Byeon HK; Kim WS; Kim JW; Choi EC; Kwon HJ; Chang JW; Koh YW Yonsei Med J 2015[Nov]; 56 (6): 1503-14 PMID26446630show ga Purpose: Although follicular thyroid cancer (FTC) has a relatively fair prognosis, distant metastasis sometimes results in poor prognosis and survival. There is little understanding of the mechanisms contributing to the aggressiveness potential of thyroid cancer. We showed that hypoxia inducible factor-1? (HIF-1?) induced aggressiveness in FTC cells and identified the underlying mechanism of the HIF-1?-induced invasive characteristics. Materials and Methods: Cells were cultured under controlled hypoxic environments (1% O2) or normoxic conditions. The effect of hypoxia on HIF-1?, and epithelial-to-mesenchymal transition (EMT) related markers were evaluated by quantitative real-time PCR, Western blot analysis and immunocytochemistry. Invasion and wound healing assay were conducted to identify functional character of EMT. The involvement of HIF-1? and Twist in EMT were studied using gene overexpression or silencing. After orthotopic nude mouse model was established using the cells transfected with lentiviral shHIF-1?, tissue analysis was done. Results: Hypoxia induces HIF-1? expression and EMT, including typical morphologic changes, cadherin shift, and increased vimentin expression. We showed that overexpression of HIF-1? via transfection resulted in the aforementioned changes without hypoxia, and repression of HIF-1? with RNA interference suppressed hypoxia-induced HIF-1? and EMT. Furthermore, we also observed that Twist expression was regulated by HIF-1?. These were confirmed in the orthotopic FTC model. Conclusion: Hypoxia induced HIF-1?, which in turn induced EMT, resulting in the increased capacity for invasion and migration of cells via regulation of the Twist signal pathway in FTC cells. These findings provide insight into a possible therapeutic strategy to prevent invasive and metastatic FTC. äHypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroi(epmc).pdf DeepDyve Pubget Overpricing