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10.1055/s-0030-1269906 http://scihub22266oqcxt.onion/10.1055/s-0030-1269906 C4629839!4629839!21210335     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuropediatrics 2010 ; 41 (5): 199-208 Nephropedia Template TP {{tp|p=21210335|t=2010. Tuberous Sclerosis Complex: Neurological, Renal and Pulmonary Manifestations |pdf=|usr=}}{{21210335}} gab.com Text Tuberous Sclerosis Complex: Neurological, Renal and Pulmonary Manifestations JO: Neuropediatrics http://www.kidney.de/pget.php?&tw=1&pmid=21210335 #FOAvip Tuberous sclerosis complex (TSC) is an important cause of epilepsy and autism, as well as renal and pulmonary disease in adults and children. Affected individuals are subject to hamartomas in various organ systems which result from constitutive activation of the protein kinase mTOR (mammalian target of rapamycin). The clinical course, prognosis and appropriate therapy for TSC patients are often different from that for individuals with epilepsy, renal tumors, or inter-stitial lung disease, from other causes. Additionally, TSC serves as a model for other conditions in which the mTOR pathways are also up-regulated. This article reviews the molecular pathophysiology and management of neurological, renal and pulmonary manifestations of the disorder. The use of mTOR inhibitors such as rapamycin and everolimus is discussed and recent clinical trials of these drugs in TSC are reviewed. Twit Text FOAVip Tuberous Sclerosis Complex: Neurological, Renal and Pulmonary Manifestations ????Neuropediatrics http://www.kidney.de/pget.php?&tw=1&pmid=21210335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21210335 #FOAvip English Wikipedia <ref>{{Cite pmid|21210335}}</ref> Tuberous Sclerosis Complex: Neurological, Renal and Pulmonary Manifestations #MMPMID21210335 Franz DN; Bissler JJ; McCormack FX Neuropediatrics 2010[Oct]; 41 (5): 199-208 PMID21210335show ga Tuberous sclerosis complex (TSC) is an important cause of epilepsy and autism, as well as renal and pulmonary disease in adults and children. Affected individuals are subject to hamartomas in various organ systems which result from constitutive activation of the protein kinase mTOR (mammalian target of rapamycin). The clinical course, prognosis and appropriate therapy for TSC patients are often different from that for individuals with epilepsy, renal tumors, or inter-stitial lung disease, from other causes. Additionally, TSC serves as a model for other conditions in which the mTOR pathways are also up-regulated. This article reviews the molecular pathophysiology and management of neurological, renal and pulmonary manifestations of the disorder. The use of mTOR inhibitors such as rapamycin and everolimus is discussed and recent clinical trials of these drugs in TSC are reviewed. äTuberous Sclerosis Complex: Neurological, Renal and Pulmonary Manifest(epmc).pdf DeepDyve Pubget Overpricing