Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26561001
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26561001
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Med+Insights+Cardiol
2015 ; 9
(Suppl 1
): 133-42
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Periodic Breathing in Heart Failure Explained by Dynamic and Static Properties of
Respiratory Control
#MMPMID26561001
Miyamoto T
; Nakahara H
; Ueda S
; Manabe K
; Kawai E
; Inagaki M
; Kawada T
; Sugimachi M
Clin Med Insights Cardiol
2015[]; 9
(Suppl 1
): 133-42
PMID26561001
show ga
OBJECTIVE: The respiratory operating point is determined by the interplay between
the controller and plant subsystem elements within the respiratory chemoreflex
feedback system. This study aimed to establish the methodological basis for
quantitative analysis of the open-loop dynamic properties of the human
respiratory control system and to apply the results to explore detailed
mechanisms of the regulation of respiration and the possible mechanism of
periodic breathing in chronic heart failure. METHODS AND RESULTS: In healthy
volunteers, we measured arterial CO2 partial pressure (PaCO2) and minute
ventilation [Formula: see text] to estimate the dynamic properties of the
controller ( [Formula: see text] relation) and plant ( [Formula: see text]
relation). The dynamic properties of the controller and plant approximated first-
and second-order exponential models, respectively, and were described using
parameters including gain, time constant, and lag time. We then used the
open-loop transfer functions to simulate the closed-loop respiratory response to
an exogenous disturbance, while manipulating the parameter values to deviate from
normal values but within physiological ranges. By increasing both the product of
gains of the two subsystem elements (total loop gain) and the lag time, the
condition of system oscillation (onset of periodic breathing) was satisfied.
CONCLUSION: When abnormality occurs in a part of the respiratory chemoreflex
system, instability of the control system is amplified and may result in the
manifestation of respiratory abnormalities such as periodic breathing.
free
free
free
