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10.1016/j.apsb.2014.03.001 http://scihub22266oqcxt.onion/10.1016/j.apsb.2014.03.001 C4629063!4629063!26579383     free     free     free       Acta+Pharm+Sin+B 2014 ; 4 (3): 193-201 Nephropedia Template TP {{tp|p=26579383|t=2014. Brain tumor-targeted drug delivery strategies |pdf=|usr=}}{{26579383}} gab.com Text Brain tumor-targeted drug delivery strategies JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579383 #FOAvip Despite the application of aggressive surgery, radiotherapy and chemotherapy in clinics, brain tumors are still a difficult health challenge due to their fast development and poor prognosis. Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments. Since brain tumors exhibit many distinctive characteristics relative to tumors growing in peripheral tissues, potential targets based on continuously changing vascular characteristics and the microenvironment can be utilized to facilitate effective brain tumor-targeted drug delivery. In this review, we briefly describe the physiological characteristics of brain tumors, including blood?brain/brain tumor barriers, the tumor microenvironment, and tumor stem cells. We also review targeted delivery strategies and introduce a systematic targeted drug delivery strategy to overcome the challenges. Twit Text FOAVip Brain tumor-targeted drug delivery strategies ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=26579383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26579383 #FOAvip English Wikipedia <ref>{{Cite pmid|26579383}}</ref> Brain tumor-targeted drug delivery strategies #MMPMID26579383 Wei X; Chen X; Ying M; Lu W Acta Pharm Sin B 2014[Jun]; 4 (3): 193-201 PMID26579383show ga Despite the application of aggressive surgery, radiotherapy and chemotherapy in clinics, brain tumors are still a difficult health challenge due to their fast development and poor prognosis. Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments. Since brain tumors exhibit many distinctive characteristics relative to tumors growing in peripheral tissues, potential targets based on continuously changing vascular characteristics and the microenvironment can be utilized to facilitate effective brain tumor-targeted drug delivery. In this review, we briefly describe the physiological characteristics of brain tumors, including blood?brain/brain tumor barriers, the tumor microenvironment, and tumor stem cells. We also review targeted delivery strategies and introduce a systematic targeted drug delivery strategy to overcome the challenges. äBrain tumor-targeted drug delivery strategies (epmc).pdf DeepDyve Pubget Overpricing