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10.1152/ajpcell.00207.2015 http://scihub22266oqcxt.onion/10.1152/ajpcell.00207.2015 C4628936!4628936 !26310815     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26310815 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hypoxia: a key player in antitumor immune response A Review in the Theme: Cellular Responses to Hypoxia |pdf=|usr=}}{{26310815 }} gab.com Text Hypoxia: a key player in antitumor immune response A Review in the Theme: Cellular Responses to Hypoxia JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26310815 #FOAvip The tumor microenvironment is a complex system, playing an important role in tumor development and progression. Besides cellular stromal components, extracellular matrix fibers, cytokines, and other metabolic mediators are also involved. In this review we outline the potential role of hypoxia, a major feature of most solid tumors, within the tumor microenvironment and how it contributes to immune resistance and immune suppression/tolerance and can be detrimental to antitumor effector cell functions. We also outline how hypoxic stress influences immunosuppressive pathways involving macrophages, myeloid-derived suppressor cells, T regulatory cells, and immune checkpoints and how it may confer tumor resistance. Finally, we discuss how microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions. Twit Text FOAVip Hypoxia: a key player in antitumor immune response A Review in the Theme: Cellular Responses to Hypoxia ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26310815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26310815 #FOAvip English Wikipedia <ref>{{Cite pmid|26310815 }}</ref> Hypoxia: a key player in antitumor immune response A Review in the Theme: Cellular Responses to Hypoxia #MMPMID26310815 Noman MZ ; Hasmim M ; Messai Y ; Terry S ; Kieda C ; Janji B ; Chouaib S Am J Physiol Cell Physiol 2015[Nov]; 309 (9 ): C569-79 PMID26310815 show ga The tumor microenvironment is a complex system, playing an important role in tumor development and progression. Besides cellular stromal components, extracellular matrix fibers, cytokines, and other metabolic mediators are also involved. In this review we outline the potential role of hypoxia, a major feature of most solid tumors, within the tumor microenvironment and how it contributes to immune resistance and immune suppression/tolerance and can be detrimental to antitumor effector cell functions. We also outline how hypoxic stress influences immunosuppressive pathways involving macrophages, myeloid-derived suppressor cells, T regulatory cells, and immune checkpoints and how it may confer tumor resistance. Finally, we discuss how microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions. |*Tumor Escape [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Cell Hypoxia [MESH] |Humans [MESH] |Hypoxia/*immunology/metabolism/pathology [MESH] |Immune Tolerance [MESH] |Immunotherapy/methods [MESH] |Lymphocytes, Tumor-Infiltrating/immunology/metabolism [MESH] |Macrophages/immunology/metabolism [MESH] |Neoplasms/*immunology/metabolism/pathology/therapy [MESH] |Oxygen/metabolism [MESH] |Signal Transduction [MESH]Hypoxia: a key player in antitumor immune response A Review in the Th(epmc).pdf DeepDyve Pubget Overpricing