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NRF2 promotes survival following exposure to ionizing radiation #MMPMID25975985
Sekhar KR; Freeman ML
Free Radic Biol Med 2015[Nov]; 88 (0 0): 268-74 PMID25975985show ga
NRF2 is a transcription factor that promotes antioxidant and drug-metabolizing gene expression. It also regulates the transcription of genes involved in carbohydrate and lipid metabolism, NADPH regeneration, heme and iron metabolism, as well as proteasome metabolism. Emerging research has identified NRF2 as a critical factor for promoting survival of mammalian cells subjected to ionizing radiation. At a mechanistic level, NRF2 promotes the repair of DNA damage and drives detoxification of superoxide that is generated hours to days after irradiation. This review summarizes research in these areas and discusses targeting of NRF2 in radiation resistant cancer and NRF2?s role in mitigating Acute Radiation Syndrome.