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10.1016/j.freeradbiomed.2015.05.043 http://scihub22266oqcxt.onion/10.1016/j.freeradbiomed.2015.05.043 C4628892!4628892!26073125     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Free+Radic+Biol+Med 2015 ; 88 (0 0): 391-403 Nephropedia Template TP {{tp|p=26073125|t=2015. RESPIRATORY SYNCYTIAL VIRUS INFECTION DOWNREGULATES ANTIOXIDANT ENZYME EXPRESSION BY TRIGGERING deacetylation-proteasomal DEGRADATION OF NRF2 |pdf=|usr=}}{{26073125}} gab.com Text RESPIRATORY SYNCYTIAL VIRUS INFECTION DOWNREGULATES ANTIOXIDANT ENZYME EXPRESSION BY TRIGGERING deacetylation-proteasomal DEGRADATION OF NRF2 JO: Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=26073125 #FOAvip Respiratory syncytial virus (RSV) is the most important cause of viral acute respiratory tract infections and hospitalizations in children, for which no vaccine or treatment is available. RSV infection in cells, mice and children leads to rapid generation of reactive oxygen species, which are associated with oxidative stress and lung damage, due to a significant decrease in the expression of airway antioxidant enzymes (AOEs). Oxidative stress plays an important role in the pathogenesis of RSV-induced lung disease, as antioxidants ameliorate clinical disease and inflammation in vivo. The aim of this study is to investigate the unknown mechanism(s) of viral-induced inhibition of AOE expression. This study shows that RSV infection induces a progressive reduction in nuclear and total cellular level of the transcription factor NF-E2-related factor 2 (NRF2), resulting in decreased binding to endogenous AOE gene promoters and decreased AOE expression. RSV induces NRF2 deacetylation and degradation via the proteasome pathway in vitro and in vivo. Histone deacetylase and proteasome inhibitors block NRF2 degradation and increase NRF2 binding to AOE endogenous promoters, resulting in increased AOE expression. Known inducers of NRF2 are able to increase NRF2 activation and subsequent AOE expression during RSV infection in vitro and in vivo, with significant amelioration of oxidative stress. This is the first study to investigate the mechanism(s) of viral-induced inhibition of AOE expression. RSV-induced inhibition of NRF2 activation, due to deacetylation and proteasomal degradation, could be targeted for therapeutic intervention aimed to increase antioxidant airway capacity during infection. Twit Text FOAVip RESPIRATORY SYNCYTIAL VIRUS INFECTION DOWNREGULATES ANTIOXIDANT ENZYME EXPRESSION BY TRIGGERING deacetylation-proteasomal DEGRADATION OF NRF2 ????Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=26073125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26073125 #FOAvip English Wikipedia <ref>{{Cite pmid|26073125}}</ref> RESPIRATORY SYNCYTIAL VIRUS INFECTION DOWNREGULATES ANTIOXIDANT ENZYME EXPRESSION BY TRIGGERING deacetylation-proteasomal DEGRADATION OF NRF2 #MMPMID26073125 Komaravelli N; Tian B; Ivanciuc T; Mautemps N; Brasier AR; Garofalo RP; Casola A Free Radic Biol Med 2015[Nov]; 88 (0 0): 391-403 PMID26073125show ga Respiratory syncytial virus (RSV) is the most important cause of viral acute respiratory tract infections and hospitalizations in children, for which no vaccine or treatment is available. RSV infection in cells, mice and children leads to rapid generation of reactive oxygen species, which are associated with oxidative stress and lung damage, due to a significant decrease in the expression of airway antioxidant enzymes (AOEs). Oxidative stress plays an important role in the pathogenesis of RSV-induced lung disease, as antioxidants ameliorate clinical disease and inflammation in vivo. The aim of this study is to investigate the unknown mechanism(s) of viral-induced inhibition of AOE expression. This study shows that RSV infection induces a progressive reduction in nuclear and total cellular level of the transcription factor NF-E2-related factor 2 (NRF2), resulting in decreased binding to endogenous AOE gene promoters and decreased AOE expression. RSV induces NRF2 deacetylation and degradation via the proteasome pathway in vitro and in vivo. Histone deacetylase and proteasome inhibitors block NRF2 degradation and increase NRF2 binding to AOE endogenous promoters, resulting in increased AOE expression. Known inducers of NRF2 are able to increase NRF2 activation and subsequent AOE expression during RSV infection in vitro and in vivo, with significant amelioration of oxidative stress. This is the first study to investigate the mechanism(s) of viral-induced inhibition of AOE expression. RSV-induced inhibition of NRF2 activation, due to deacetylation and proteasomal degradation, could be targeted for therapeutic intervention aimed to increase antioxidant airway capacity during infection. äRESPIRATORY SYNCYTIAL VIRUS INFECTION DOWNREGULATES ANTIOXIDANT ENZYME(epmc).pdf DeepDyve Pubget Overpricing