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10.1016/j.bmcl.2015.09.036

http://scihub22266oqcxt.onion/10.1016/j.bmcl.2015.09.036
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C4628877!4628877!26420066
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suck abstract from ncbi


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pmid26420066      Bioorg+Med+Chem+Lett 2015 ; 25 (22): 5349-51
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  • Benzophenone and its analogs bind to human glyoxalase 1 #MMPMID26420066
  • Mihai DM; Hall S; Deng H; Welch CJ; Kawamura A
  • Bioorg Med Chem Lett 2015[Nov]; 25 (22): 5349-51 PMID26420066show ga
  • Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed.
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