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10.1016/j.tcb.2015.07.013

http://scihub22266oqcxt.onion/10.1016/j.tcb.2015.07.013
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C4628848!4628848!26437597
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suck abstract from ncbi


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pmid26437597      Trends+Cell+Biol 2015 ; 25 (11): 666-74
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  • Fibroblasts lead the way: a unified view of three-dimensional cell motility #MMPMID26437597
  • Petrie RJ; Yamada KM
  • Trends Cell Biol 2015[Nov]; 25 (11): 666-74 PMID26437597show ga
  • Primary human fibroblasts are remarkably adaptable, able to migrate in differing types of physiological 3D tissue and on rigid 2D tissue culture surfaces. The crawling behavior of these and other vertebrate cells has been studied intensively, which has helped generate the concept of the cell motility cycle as a comprehensive model of 2D cell migration. However, this model fails to explain how cells force their large nuclei through the confines of a 3D matrix environment and why primary fibroblasts can use more than one mechanism to move in 3D. Recent work shows that the intracellular localization of myosin II activity is governed by cell-matrix interactions to both force the nucleus through the extracellular matrix and dictate the type of protrusions used to migrate in 3D.
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