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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Cell+Biol 2015 ; 25 (11): 675-86 Nephropedia Template TP
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Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression #MMPMID26437589
Ye X; Weinberg RA
Trends Cell Biol 2015[Nov]; 25 (11): 675-86 PMID26437589show ga
The epithelial-mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage through an EMT and acquisition of stem-like properties indicates that activation of the EMT programs serves as a major mechanism for generating cancer stem cells, i.e., the cells that are responsible for initiating and propagating the disease. In this review, we summarize the evidence supporting the widespread involvement of the EMT program in tumor pathogenesis and attempt to rationalize the connection between the EMT program and acquisition of stem-cell traits. We propose that the epithelial-mesenchymal plasticity is likely controlled by multiple varients of the core EMT program and foresee the need to resolve the various programs and the molecular mechanisms that underlie them.