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10.1007/s00253-015-6963-9 http://scihub22266oqcxt.onion/10.1007/s00253-015-6963-9 C4628842!4628842!26363557     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26363557&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Appl+Microbiol+Biotechnol 2015 ; 99 (22): 9381-93 Nephropedia Template TP {{tp|p=26363557|t=2015. Efflux Systems in Bacteria and their Metabolic Engineering Applications |pdf=|usr=}}{{26363557}} gab.com Text Efflux Systems in Bacteria and their Metabolic Engineering Applications JO: Appl Microbiol Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=26363557 #FOAvip The production of valuable chemicals from metabolically engineered microbes can be limited by excretion from the cell. Efflux is often overlooked as a bottleneck in metabolic pathways, despite its impact on alleviating feedback inhibition and product toxicity. In the past, it has been assumed that endogenous efflux pumps and membrane porins can accommodate product efflux rates, however, there are an increasing number of examples wherein overexpressing efflux systems is required to improve metabolite production. In this review, we highlight specific examples from the literature where metabolite export has been studied to identify unknown transporters, increase tolerance to metabolites, and improve the production capabilities of engineered bacteria. The review focuses on the export of a broad spectrum of valuable chemicals including amino acids, sugars, flavins, biofuels and solvents. The combined set of examples supports the hypothesis that efflux systems can be identified and engineered to confer export capabilities on industrially relevant microbes. Twit Text FOAVip Efflux Systems in Bacteria and their Metabolic Engineering Applications ????Appl Microbiol Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=26363557 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26363557 #FOAvip English Wikipedia <ref>{{Cite pmid|26363557}}</ref> Efflux Systems in Bacteria and their Metabolic Engineering Applications #MMPMID26363557 Jones CM; Hernández Lozada NJ; Pfleger BF Appl Microbiol Biotechnol 2015[Nov]; 99 (22): 9381-93 PMID26363557show ga The production of valuable chemicals from metabolically engineered microbes can be limited by excretion from the cell. Efflux is often overlooked as a bottleneck in metabolic pathways, despite its impact on alleviating feedback inhibition and product toxicity. In the past, it has been assumed that endogenous efflux pumps and membrane porins can accommodate product efflux rates, however, there are an increasing number of examples wherein overexpressing efflux systems is required to improve metabolite production. In this review, we highlight specific examples from the literature where metabolite export has been studied to identify unknown transporters, increase tolerance to metabolites, and improve the production capabilities of engineered bacteria. The review focuses on the export of a broad spectrum of valuable chemicals including amino acids, sugars, flavins, biofuels and solvents. The combined set of examples supports the hypothesis that efflux systems can be identified and engineered to confer export capabilities on industrially relevant microbes. äEfflux Systems in Bacteria and their Metabolic Engineering Application(epmc).pdf DeepDyve Pubget Overpricing