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10.1016/j.jaut.2015.08.015 http://scihub22266oqcxt.onion/10.1016/j.jaut.2015.08.015 C4628839!4628839 !26343334     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26343334 &cmd=llinks): Failed to open stream: HTTP request failed! 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The genetics of human autoimmune disease: A perspective on progress in the field and future directions |pdf=|usr=}}{{26343334 }} gab.com Text The genetics of human autoimmune disease: A perspective on progress in the field and future directions JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=26343334 #FOAvip Progress in defining the genetics of autoimmune disease has been dramatically enhanced by large scale genetic studies. Genome-wide approaches, examining hundreds or for some diseases thousands of cases and controls, have been implemented using high throughput genotyping and appropriate algorithms to provide a wealth of data over the last decade. These studies have identified hundreds of non-HLA loci as well as further defining HLA variations that predispose to different autoimmune diseases. These studies to identify genetic risk loci are also complemented by progress in gene expression studies including definition of expression quantitative trait loci (eQTL), various alterations in chromatin structure including histone marks, DNase I sensitivity, repressed chromatin regions as well as transcript factor binding sites. Integration of this information can partially explain why particular variations can alter proclivity to autoimmune phenotypes. Despite our incomplete knowledge base with only partial definition of hereditary factors and possible functional connections, this progress has and will continue to facilitate a better understanding of critical pathways and critical changes in immunoregulation. Advances in defining and understanding functional variants potentially can lead to both novel therapeutics and personalized medicine in which therapeutic approaches are chosen based on particular molecular phenotypes and genomic alterations. Twit Text FOAVip The genetics of human autoimmune disease: A perspective on progress in the field and future directions ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=26343334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26343334 #FOAvip English Wikipedia <ref>{{Cite pmid|26343334 }}</ref> The genetics of human autoimmune disease: A perspective on progress in the field and future directions #MMPMID26343334 Seldin MF J Autoimmun 2015[Nov]; 64 (ä): 1-12 PMID26343334 show ga Progress in defining the genetics of autoimmune disease has been dramatically enhanced by large scale genetic studies. Genome-wide approaches, examining hundreds or for some diseases thousands of cases and controls, have been implemented using high throughput genotyping and appropriate algorithms to provide a wealth of data over the last decade. These studies have identified hundreds of non-HLA loci as well as further defining HLA variations that predispose to different autoimmune diseases. These studies to identify genetic risk loci are also complemented by progress in gene expression studies including definition of expression quantitative trait loci (eQTL), various alterations in chromatin structure including histone marks, DNase I sensitivity, repressed chromatin regions as well as transcript factor binding sites. Integration of this information can partially explain why particular variations can alter proclivity to autoimmune phenotypes. Despite our incomplete knowledge base with only partial definition of hereditary factors and possible functional connections, this progress has and will continue to facilitate a better understanding of critical pathways and critical changes in immunoregulation. Advances in defining and understanding functional variants potentially can lead to both novel therapeutics and personalized medicine in which therapeutic approaches are chosen based on particular molecular phenotypes and genomic alterations. |*Genetic Association Studies [MESH] |*Genetic Predisposition to Disease [MESH] |Animals [MESH] |Autoimmune Diseases/diagnosis/*genetics/immunology/therapy [MESH] |Epigenesis, Genetic [MESH] |Epistasis, Genetic [MESH] |Gene Expression Regulation [MESH] |Genetic Loci [MESH] |Genetic Variation [MESH] |Genome-Wide Association Study [MESH] |Genomics [MESH] |Humans [MESH] |Major Histocompatibility Complex/genetics/immunology [MESH]The genetics of human autoimmune disease: A perspective on progress in(epmc).pdf DeepDyve Pubget Overpricing