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10.1038/nrd4593 http://scihub22266oqcxt.onion/10.1038/nrd4593 C4628595!4628595!26338154     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Drug+Discov 2015 ; 14 (11): 759-80 Nephropedia Template TP {{tp|p=26338154|t=2015. Targeting Protein Aggregation for the Treatment of Degenerative Diseases |pdf=|usr=}}{{26338154}} gab.com Text Targeting Protein Aggregation for the Treatment of Degenerative Diseases JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=26338154 #FOAvip The aggregation of specific proteins is hypothesized to underlie several degenerative diseases, collectively called amyloid disorders. However, the mechanistic connection between the process of protein aggregation and tissue degeneration is not yet fully understood. Here, we review current and emerging strategies to ameliorate aggregation-associated degenerative disorders, with a focus on disease-modifying strategies that prevent the formation of and/or eliminate protein aggregates. Persuasive pharmacologic and genetic evidence now support protein aggregation as the cause of post-mitotic tissue dysfunction or loss. However, a more detailed understanding of the factors that trigger and sustain aggregate formation, as well as the structure-activity relationships underlying proteotoxicity are needed to develop future disease-modifying therapies. Twit Text FOAVip Targeting Protein Aggregation for the Treatment of Degenerative Diseases ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=26338154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26338154 #FOAvip English Wikipedia <ref>{{Cite pmid|26338154}}</ref> Targeting Protein Aggregation for the Treatment of Degenerative Diseases #MMPMID26338154 Eisele YS; Monteiro C; Fearns C; Encalada SE; Wiseman RL; Powers ET; Kelly JW Nat Rev Drug Discov 2015[Nov]; 14 (11): 759-80 PMID26338154show ga The aggregation of specific proteins is hypothesized to underlie several degenerative diseases, collectively called amyloid disorders. However, the mechanistic connection between the process of protein aggregation and tissue degeneration is not yet fully understood. Here, we review current and emerging strategies to ameliorate aggregation-associated degenerative disorders, with a focus on disease-modifying strategies that prevent the formation of and/or eliminate protein aggregates. Persuasive pharmacologic and genetic evidence now support protein aggregation as the cause of post-mitotic tissue dysfunction or loss. However, a more detailed understanding of the factors that trigger and sustain aggregate formation, as well as the structure-activity relationships underlying proteotoxicity are needed to develop future disease-modifying therapies. äTargeting Protein Aggregation for the Treatment of Degenerative Diseas(epmc).pdf DeepDyve Pubget Overpricing