Meningitis caused by Pasteurella multocida in a dog owner without a dog bite:
clonal lineage identification by MALDI-TOF mass spectrometry
#MMPMID26521235
Bardou M
; Honnorat E
; Dubourg G
; Couderc C
; Fournier PE
; Seng P
; Stein A
BMC Res Notes
2015[Oct]; 8
(?): 626
PMID26521235
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BACKGROUND: Pasteurella multocida meningitis in an immunocompetent patient is
rare and commonly occurs after animal bite. To our knowledge, only 48 cases have
been reported in the literature since 1989. P. multocida meningitis is commonly
linked to animal contagion. Here we report on a new case of P. multocida
meningitis in an immunocompetent patient who is a dog owner without a dog bite.
We used the matrix-assisted laser desorption/ionization-time of flight
(MALDI-TOF) mass spectrometry to investigate the clonal lineage between animal
and human isolates. CASE PRESENTATION: In our case, a 25-year-old immunocompetent
French Caucasian woman with nothing notable in her medical history was admitted
for meningitis caused by P. multocida. Clonal lineage of P. multocida strains
from cerebrospinal fluid and blood culture and her dog's oral cavity has been
recognized by MALDI-TOF mass spectrometry dendrograms and clustering of the 21 P.
multocida isolates in our centres. She was treated by a combination of
intravenous ceftriaxone (2 g/day) and oral levofloxacin (1 g/day). She was
discharged on the 6th day of admission. The antimicrobial therapy was conducted
for 15 days. The dog was treated by clavulanic-acid amoxicillin for 3 weeks by
the veterinarian. The evolution of the patient at the 5th month after the end of
the antimicrobial therapy was normal without any neurological after-effects.
CONCLUSION: The meningitis caused by P. multocida could be considered a cause of
human meningitis in dog lovers without an animal bite. MALDI-TOF mass
spectrometry should be considered as it is an accurate tool to identify clonal
lineage between animal and human isolates.
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