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10.1210/me.2015-1145 http://scihub22266oqcxt.onion/10.1210/me.2015-1145 C4627603!4627603 !26407237     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26407237 &cmd=llinks): Failed to open stream: HTTP request failed! 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CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1? |pdf=|usr=}}{{26407237 }} gab.com Text CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1 JO: Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26407237 #FOAvip The constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor gamma coactivator-1? (PGC1?) are master regulators of drug metabolism and gluconeogenesis, respectively. In supporting the cross talk between drug metabolism and energy metabolism, activation of CAR has been shown to suppress hepatic gluconeogenesis and ameliorate hyperglycemia in vivo, but the underlying molecular mechanism remains elusive. In this study, we demonstrated that CAR suppressed hepatic gluconeogenic gene expression through posttranslational regulation of the subcellular localization and degradation of PGC1?. Activated CAR translocated into the nucleus and served as an adaptor protein to recruit PGC1? to the Cullin1 E3 ligase complex for ubiquitination. The interaction between CAR and PGC1? also led to their sequestration within the promyelocytic leukemia protein-nuclear bodies, where PGC1? and CAR subsequently underwent proteasomal degradation. Taken together, our findings revealed an unexpected function of CAR in recruiting an E3 ligase and targeting the gluconeogenic activity of PGC1?. Both drug metabolism and gluconeogenesis are energy-demanding processes. The negative regulation of PGC1? by CAR may represent a cellular adaptive mechanism to accommodate energy-restricted conditions. Twit Text FOAVip CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1 ????Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26407237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26407237 #FOAvip English Wikipedia <ref>{{Cite pmid|26407237 }}</ref> CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1? #MMPMID26407237 Gao J ; Yan J ; Xu M ; Ren S ; Xie W Mol Endocrinol 2015[Nov]; 29 (11 ): 1558-70 PMID26407237 show ga The constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor gamma coactivator-1? (PGC1?) are master regulators of drug metabolism and gluconeogenesis, respectively. In supporting the cross talk between drug metabolism and energy metabolism, activation of CAR has been shown to suppress hepatic gluconeogenesis and ameliorate hyperglycemia in vivo, but the underlying molecular mechanism remains elusive. In this study, we demonstrated that CAR suppressed hepatic gluconeogenic gene expression through posttranslational regulation of the subcellular localization and degradation of PGC1?. Activated CAR translocated into the nucleus and served as an adaptor protein to recruit PGC1? to the Cullin1 E3 ligase complex for ubiquitination. The interaction between CAR and PGC1? also led to their sequestration within the promyelocytic leukemia protein-nuclear bodies, where PGC1? and CAR subsequently underwent proteasomal degradation. Taken together, our findings revealed an unexpected function of CAR in recruiting an E3 ligase and targeting the gluconeogenic activity of PGC1?. Both drug metabolism and gluconeogenesis are energy-demanding processes. The negative regulation of PGC1? by CAR may represent a cellular adaptive mechanism to accommodate energy-restricted conditions. |Animals [MESH] |Cell Line [MESH] |Constitutive Androstane Receptor [MESH] |Energy Metabolism/physiology [MESH] |Gene Expression Regulation/*genetics [MESH] |Gluconeogenesis/*physiology [MESH] |Glucose/metabolism [MESH] |Inactivation, Metabolic/genetics/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Nuclear Proteins/metabolism [MESH] |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [MESH] |Promyelocytic Leukemia Protein [MESH] |Protein Structure, Tertiary [MESH] |Proteolysis [MESH] |RNA Interference [MESH] |RNA Processing, Post-Transcriptional/genetics [MESH] |RNA, Small Interfering/genetics [MESH] |Receptors, Cytoplasmic and Nuclear/genetics/*metabolism [MESH] |Transcription Factors/*antagonists & inhibitors/metabolism [MESH] |Tumor Suppressor Proteins/metabolism [MESH] |Ubiquitin-Protein Ligases/metabolism [MESH]CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitinat(epmc).pdf DeepDyve Pubget Overpricing