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10.18632/oncotarget.3756 http://scihub22266oqcxt.onion/10.18632/oncotarget.3756 C4627336!4627336 !25974964     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25974964 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (19 ): 17661-74 Nephropedia Template TP {{tp|p=25974964 |t=2015. Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-?1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit |pdf=|usr=}}{{25974964 }} gab.com Text Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF- 1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25974964 #FOAvip Some feedback pathways are critical in the process of tumor development or malignant progression. However the mechanisms through which these pathways are epigenetically regulated have not been fully elucidated. Here, we demonstrated that the histone demethylase RBP2 was crucial for TGF-?1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit that was implicated in malignant progression of tumors and its knockdown significantly inhibited gastric cancer (GC) metastasis both in vitro and in vivo. Mechanistically, RBP2 can directly bind to E-cadherin promoter and suppress its expression, facilitating EMT and distant metastasis of GC. RBP2 can also be induced by TGF-?1, a key inducer of EMT, through phosphorylated Smad3 (p-Smad3) pathway in GC. The upregulated RBP2 can be recruited by p-smad3 to E-cadherin promoter and enhance its suppression, contributing to the promotion of metastasis of GC. In addition, the suppression of E-cadherin by RBP2 attenuated inhibition of Smad3 phosphorylation (exerted by E-cadherin), resulting further induction of RBP2 expression, and thus constituting positive feedback regulation during GC malignant progression. This TGF-?1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit may be a novel mechanism for GC malignant progression and suppression of RBP2 expression may serve as a new strategy for the prevention of tumor distant metastasis. Twit Text FOAVip Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF- 1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25974964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25974964 #FOAvip English Wikipedia <ref>{{Cite pmid|25974964 }}</ref> Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-?1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit #MMPMID25974964 Liang X ; Zeng J ; Wang L ; Shen L ; Ma X ; Li S ; Wu Y ; Ma L ; Ci X ; Guo Q ; Jia M ; Shen H ; Sun Y ; Liu Z ; Liu S ; Li W ; Yu H ; Chen C ; Jia J Oncotarget 2015[Jul]; 6 (19 ): 17661-74 PMID25974964 show ga Some feedback pathways are critical in the process of tumor development or malignant progression. However the mechanisms through which these pathways are epigenetically regulated have not been fully elucidated. Here, we demonstrated that the histone demethylase RBP2 was crucial for TGF-?1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit that was implicated in malignant progression of tumors and its knockdown significantly inhibited gastric cancer (GC) metastasis both in vitro and in vivo. Mechanistically, RBP2 can directly bind to E-cadherin promoter and suppress its expression, facilitating EMT and distant metastasis of GC. RBP2 can also be induced by TGF-?1, a key inducer of EMT, through phosphorylated Smad3 (p-Smad3) pathway in GC. The upregulated RBP2 can be recruited by p-smad3 to E-cadherin promoter and enhance its suppression, contributing to the promotion of metastasis of GC. In addition, the suppression of E-cadherin by RBP2 attenuated inhibition of Smad3 phosphorylation (exerted by E-cadherin), resulting further induction of RBP2 expression, and thus constituting positive feedback regulation during GC malignant progression. This TGF-?1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit may be a novel mechanism for GC malignant progression and suppression of RBP2 expression may serve as a new strategy for the prevention of tumor distant metastasis. |Animals [MESH] |Cadherins/metabolism [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition/physiology [MESH] |Feedback, Physiological/physiology [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Heterografts [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Phosphorylation [MESH] |Retinol-Binding Proteins, Cellular/*metabolism [MESH] |Signal Transduction/*physiology [MESH] |Smad3 Protein/metabolism [MESH] |Stomach Neoplasms/metabolism/*pathology [MESH]Histone demethylase RBP2 promotes malignant progression of gastric can(epmc).pdf DeepDyve Pubget Overpricing