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10.3390/ijerph121012426 http://scihub22266oqcxt.onion/10.3390/ijerph121012426 C4626977!4626977!26445054     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26445054&cmd=llinks): Failed to open stream: HTTP request failed! 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Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features |pdf=|usr=}}{{26445054}} gab.com Text Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features JO: Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=26445054 #FOAvip Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor ? (ER?) estrogen receptor ? (ER?), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor ? (PPAR?) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPAR?, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ER?, ER?, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health. Twit Text FOAVip Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features ????Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=26445054 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26445054 #FOAvip English Wikipedia <ref>{{Cite pmid|26445054}}</ref> Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features #MMPMID26445054 La Rocca C; Tait S; Guerranti C; Busani L; Ciardo F; Bergamasco B; Perra G; Mancini FR; Marci R; Bordi G; Caserta D; Focardi S; Moscarini M; Mantovani A Int J Environ Res Public Health 2015[Oct]; 12 (10): 12426-45 PMID26445054show ga Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor ? (ER?) estrogen receptor ? (ER?), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor ? (PPAR?) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPAR?, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ER?, ER?, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health. äExposure to Endocrine Disruptors and Nuclear Receptors Gene Expression(epmc).pdf DeepDyve Pubget Overpricing