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10.1093/femspd/ftv073 http://scihub22266oqcxt.onion/10.1093/femspd/ftv073 C4626579!4626579!26394801     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pathog+Dis 2015 ; 73 (8): ä Nephropedia Template TP {{tp|p=26394801|t=2015. Contribution of pertussis toxin to the pathogenesis of pertussis disease |pdf=|usr=}}{{26394801}} gab.com Text Contribution of pertussis toxin to the pathogenesis of pertussis disease JO: Pathog Dis http://www.kidney.de/pget.php?&tw=1&pmid=26394801 #FOAvip Pertussis toxin (PT) is a multisubunit protein toxin secreted by Bordetella pertussis, the bacterial agent of the disease pertussis or whooping cough. PT in detoxified form is a component of all licensed acellular pertussis vaccines, since it is considered to be an important virulence factor for this pathogen. PT inhibits G protein-coupled receptor signaling through Gi proteins in mammalian cells, an activity that has led to its widespread use as a cell biology tool. But how does this activity of PT contribute to pertussis, including the severe respiratory symptoms of this disease? In this minireview, the contribution of PT to the pathogenesis of pertussis disease will be considered based on evidence from both human infections and animal model studies. Although definitive proof of the role of PT in humans is lacking, substantial evidence supports the idea that PT is a major contributor to pertussis pathology, including the severe respiratory symptoms associated with this disease. Twit Text FOAVip Contribution of pertussis toxin to the pathogenesis of pertussis disease ????Pathog Dis http://www.kidney.de/pget.php?&tw=1&pmid=26394801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26394801 #FOAvip English Wikipedia <ref>{{Cite pmid|26394801}}</ref> Contribution of pertussis toxin to the pathogenesis of pertussis disease #MMPMID26394801 Carbonetti NH Pathog Dis 2015[Nov]; 73 (8): ä PMID26394801show ga Pertussis toxin (PT) is a multisubunit protein toxin secreted by Bordetella pertussis, the bacterial agent of the disease pertussis or whooping cough. PT in detoxified form is a component of all licensed acellular pertussis vaccines, since it is considered to be an important virulence factor for this pathogen. PT inhibits G protein-coupled receptor signaling through Gi proteins in mammalian cells, an activity that has led to its widespread use as a cell biology tool. But how does this activity of PT contribute to pertussis, including the severe respiratory symptoms of this disease? In this minireview, the contribution of PT to the pathogenesis of pertussis disease will be considered based on evidence from both human infections and animal model studies. Although definitive proof of the role of PT in humans is lacking, substantial evidence supports the idea that PT is a major contributor to pertussis pathology, including the severe respiratory symptoms associated with this disease. äContribution of pertussis toxin to the pathogenesis of pertussis disea(epmc).pdf DeepDyve Pubget Overpricing