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10.1038/nn.4069 http://scihub22266oqcxt.onion/10.1038/nn.4069 C4625987!4625987!26214369     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2015 ; 18 (9): 1256-64 Nephropedia Template TP {{tp|p=26214369|t=2015. LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control |pdf=|usr=}}{{26214369}} gab.com Text LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26214369 #FOAvip We report that a neuron-specific isoform of LSD1, LSD1n, resulting from an alternative splicing event, acquires a novel substrate specificity targeting histone H4 K20 methylation, both in vitro and in vivo. Selective genetic ablation of LSD1n leads to deficits in spatial learning and memory, revealing the functional importance of LSD1n in the regulation of neuronal activity-regulated transcription in a fashion indispensable for long-term memory formation. LSD1n occupies neuronal gene enhancers, promoters and transcribed coding regions, and is required for transcription initiation and elongation steps in response to neuronal activity, indicating the crucial role of H4K20 methylation in coordinating gene transcription with neuronal function. This study reveals that the alternative splicing of LSD1 in neurons, associated with altered substrate specificity, serves as an underlying mechanism acquired by neurons to achieve more precise control of gene expression in the complex processes underlying learning and memory. Twit Text FOAVip LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26214369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26214369 #FOAvip English Wikipedia <ref>{{Cite pmid|26214369}}</ref> LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control #MMPMID26214369 Wang J; Telese F; Tan Y; Li W; Jin C; He X; Basnet H; Ma Q; Merkurjev D; Zhu X; Liu Z; Zhang J; Ohgi K; Taylor H; White RR; Macfarlan TS; Pfaff SL; Rosenfeld MG Nat Neurosci 2015[Sep]; 18 (9): 1256-64 PMID26214369show ga We report that a neuron-specific isoform of LSD1, LSD1n, resulting from an alternative splicing event, acquires a novel substrate specificity targeting histone H4 K20 methylation, both in vitro and in vivo. Selective genetic ablation of LSD1n leads to deficits in spatial learning and memory, revealing the functional importance of LSD1n in the regulation of neuronal activity-regulated transcription in a fashion indispensable for long-term memory formation. LSD1n occupies neuronal gene enhancers, promoters and transcribed coding regions, and is required for transcription initiation and elongation steps in response to neuronal activity, indicating the crucial role of H4K20 methylation in coordinating gene transcription with neuronal function. This study reveals that the alternative splicing of LSD1 in neurons, associated with altered substrate specificity, serves as an underlying mechanism acquired by neurons to achieve more precise control of gene expression in the complex processes underlying learning and memory. äLSD1n is a H4K20 demethylase regulating memory formation via transcrip(epmc).pdf DeepDyve Pubget Overpricing