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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Am+Soc+Mass+Spectrom
2015 ; 26
(11
): 1804-13
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Pivotal role of computers and software in mass spectrometry - SEQUEST and 20
years of tandem MS database searching
#MMPMID26286455
Yates JR 3rd
J Am Soc Mass Spectrom
2015[Nov]; 26
(11
): 1804-13
PMID26286455
show ga
Advances in computer technology and software have driven developments in mass
spectrometry over the last 50 years. Computers and software have been impactful
in three areas: the automation of difficult calculations to aid interpretation,
the collection of data and control of instruments, and data interpretation. As
the power of computers has grown, so too has the utility and impact on mass
spectrometers and their capabilities. This has been particularly evident in the
use of tandem mass spectrometry data to search protein and nucleotide sequence
databases to identify peptide and protein sequences. This capability has driven
the development of many new approaches to study biological systems, including the
use of "bottom-up shotgun proteomics" to directly analyze protein mixtures.
Graphical Abstract ?.