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2009 ; 78
(ä): 673-99
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Proton-coupled electron transfer in biology: results from synergistic studies in
natural and model systems
#MMPMID19344235
Reece SY
; Nocera DG
Annu Rev Biochem
2009[]; 78
(ä): 673-99
PMID19344235
show ga
Proton-coupled electron transfer (PCET) underpins energy conversion in biology.
PCET may occur with the unidirectional or bidirectional transfer of a proton and
electron and may proceed synchronously or asynchronously. To illustrate the role
of PCET in biology, this review presents complementary biological and model
systems that explore PCET in electron transfer (ET) through hydrogen bonds
[azurin as compared to donor-acceptor (D-A) hydrogen-bonded networks], the
activation of C-H bonds [alcohol dehydrogenase and soybean lipoxygenase (SLO) as
compared to Fe(III) metal complexes], and the generation and transport of amino
acid radicals [photosystem II (PSII) and ribonucleotide reductase (RNR) as
compared to tyrosine-modified photoactive Re(I) and Ru(II) complexes]. In
providing these comparisons, the fundamental principles of PCET in biology are
illustrated in a tangible way.