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10.1681/ASN.2015010052

http://scihub22266oqcxt.onion/10.1681/ASN.2015010052
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C4625683!4625683!25999405
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suck abstract from ncbi

pmid25999405      J+Am+Soc+Nephrol 2015 ; 26 (11): 2612-9
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  • The Labile Side of Iron Supplementation in CKD #MMPMID25999405
  • Slotki I; Cabantchik ZI
  • J Am Soc Nephrol 2015[Nov]; 26 (11): 2612-9 PMID25999405show ga
  • The practice of intravenous iron supplementation has grown as nephrologists have gradually moved away from the liberal use of erythropoiesis-stimulating agents as the main treatment for the anemia of CKD. This approach, together with the introduction of large-dose iron preparations, raises the future specter of inadvertent iatrogenic iron toxicity. Concerns have been raised in original studies and reviews about cardiac complications and severe infections that result from long-term intravenous iron supplementation. Regarding the iron preparations specifically, even though all the currently available preparations appear to be relatively safe in the short term, little is known regarding their long-term safety. In this review we summarize current knowledge of iron metabolism with an emphasis on the sources and potentially harmful effects of labile iron, highlight the approaches to identifying labile iron in pharmaceutical preparations and body fluids and its potential toxic role as a pathogenic factor in the complications of CKD, and propose methods for its early detection in at-risk patients.
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