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10.1681/ASN.2014090853 http://scihub22266oqcxt.onion/10.1681/ASN.2014090853 C4625675!4625675!25788524     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2015 ; 26 (11): 2691-702 Nephropedia Template TP {{tp|p=25788524|t=2015. Store?Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression |pdf=|usr=}}{{25788524}} gab.com Text Store Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25788524 #FOAvip Accumulation of extracellular matrix derived from glomerular mesangial cells is an early feature of diabetic nephropathy. Ca2+ signals mediated by store?operated Ca2+ channels regulate protein production in a variety of cell types. The aim of this study was to determine the effect of store?operated Ca2+ channels in mesangial cells on extracellular matrix protein expression. In cultured human mesangial cells, activation of store?operated Ca2+ channels by thapsigargin significantly decreased fibronectin protein expression and collagen IV mRNA expression in a dose-dependent manner. Conversely, inhibition of the channels by 2-aminoethyl diphenylborinate significantly increased the expression of fibronectin and collagen IV. Similarly, overexpression of stromal interacting molecule 1 reduced, but knockdown of calcium release?activated calcium channel protein 1 (Orai1) increased fibronectin protein expression. Furthermore, 2-aminoethyl diphenylborinate significantly augmented angiotensin II?induced fibronectin protein expression, whereas thapsigargin abrogated high glucose? and TGF-?1?stimulated matrix protein expression. In vivo knockdown of Orai1 in mesangial cells of mice using a targeted nanoparticle siRNA delivery system resulted in increased expression of glomerular fibronectin and collagen IV, and mice showed significant mesangial expansion compared with controls. Similarly, in vivo knockdown of stromal interacting molecule 1 in mesangial cells by recombinant adeno?associated virus?encoded shRNA markedly increased collagen IV protein expression in renal cortex and caused mesangial expansion in rats. These results suggest that store?operated Ca2+ channels in mesangial cells negatively regulate extracellular matrix protein expression in the kidney, which may serve as an endogenous renoprotective mechanism in diabetes. Twit Text FOAVip Store Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25788524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25788524 #FOAvip English Wikipedia <ref>{{Cite pmid|25788524}}</ref> Store?Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression #MMPMID25788524 Wu P; Wang Y; Davis ME; Zuckerman JE; Chaudhari S; Begg M; Ma R J Am Soc Nephrol 2015[Nov]; 26 (11): 2691-702 PMID25788524show ga Accumulation of extracellular matrix derived from glomerular mesangial cells is an early feature of diabetic nephropathy. Ca2+ signals mediated by store?operated Ca2+ channels regulate protein production in a variety of cell types. The aim of this study was to determine the effect of store?operated Ca2+ channels in mesangial cells on extracellular matrix protein expression. In cultured human mesangial cells, activation of store?operated Ca2+ channels by thapsigargin significantly decreased fibronectin protein expression and collagen IV mRNA expression in a dose-dependent manner. Conversely, inhibition of the channels by 2-aminoethyl diphenylborinate significantly increased the expression of fibronectin and collagen IV. Similarly, overexpression of stromal interacting molecule 1 reduced, but knockdown of calcium release?activated calcium channel protein 1 (Orai1) increased fibronectin protein expression. Furthermore, 2-aminoethyl diphenylborinate significantly augmented angiotensin II?induced fibronectin protein expression, whereas thapsigargin abrogated high glucose? and TGF-?1?stimulated matrix protein expression. In vivo knockdown of Orai1 in mesangial cells of mice using a targeted nanoparticle siRNA delivery system resulted in increased expression of glomerular fibronectin and collagen IV, and mice showed significant mesangial expansion compared with controls. Similarly, in vivo knockdown of stromal interacting molecule 1 in mesangial cells by recombinant adeno?associated virus?encoded shRNA markedly increased collagen IV protein expression in renal cortex and caused mesangial expansion in rats. These results suggest that store?operated Ca2+ channels in mesangial cells negatively regulate extracellular matrix protein expression in the kidney, which may serve as an endogenous renoprotective mechanism in diabetes. äStore?Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein(epmc).pdf DeepDyve Pubget Overpricing