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10.1016/j.jaut.2014.05.007 http://scihub22266oqcxt.onion/10.1016/j.jaut.2014.05.007 C4625610!4625610!24934597     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Autoimmun 2014 ; 55 (ä): 51-62 Nephropedia Template TP {{tp|p=24934597|t=2014. Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression |pdf=|usr=}}{{24934597}} gab.com Text Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=24934597 #FOAvip Although FoxP3+ regulatory T cells are key players in the maintenance of immune tolerance and autoimmunity, the lack of specific markers constitute an obstacle to their use for immunotherapy protocols. In this study, we have investigated the role of the C-type lectin receptor CD69 in the suppressor function of Tregs and maintenance of immune tolerance towards harmless inhaled antigens. We identified a novel FoxP3+CD69+ Treg subset capable to maintain immune tolerance and protect to developing inflammation. Although CD69+ and CD69?FoxP3+ Tregs exist in homeostasis, only CD69-expressing Tregs express high levels of CTLA-4, ICOS, CD38 and GITR suppression-associated markers, secrete high amounts of TGF? ??? have potent suppressor activity. This activity is regulated by STAT5 and ERK signaling pathways and is impaired by antibody-mediated down-regulation of CD69 expression. Moreover, immunotherapy with FoxP3+CD69+ Tregs restores the homeostasis in Cd69?/? mice, that fail to induce tolerance, and is also highly proficient in the prevention of inflammation. The identification of the FoxP3+CD69+ Treg subset paves the way toward the development of new therapeutic strategies to control immune homeostasis and autoimmunity. Twit Text FOAVip Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=24934597 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24934597 #FOAvip English Wikipedia <ref>{{Cite pmid|24934597}}</ref> Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression #MMPMID24934597 Cortés JR; Sánchez-Díaz R; Bovolenta ER; Barreiro O; Lasarte S; Matesanz-Marín A; Toribio ML; Sánchez-Madrid F; Martín P J Autoimmun 2014[Dec]; 55 (ä): 51-62 PMID24934597show ga Although FoxP3+ regulatory T cells are key players in the maintenance of immune tolerance and autoimmunity, the lack of specific markers constitute an obstacle to their use for immunotherapy protocols. In this study, we have investigated the role of the C-type lectin receptor CD69 in the suppressor function of Tregs and maintenance of immune tolerance towards harmless inhaled antigens. We identified a novel FoxP3+CD69+ Treg subset capable to maintain immune tolerance and protect to developing inflammation. Although CD69+ and CD69?FoxP3+ Tregs exist in homeostasis, only CD69-expressing Tregs express high levels of CTLA-4, ICOS, CD38 and GITR suppression-associated markers, secrete high amounts of TGF? ??? have potent suppressor activity. This activity is regulated by STAT5 and ERK signaling pathways and is impaired by antibody-mediated down-regulation of CD69 expression. Moreover, immunotherapy with FoxP3+CD69+ Tregs restores the homeostasis in Cd69?/? mice, that fail to induce tolerance, and is also highly proficient in the prevention of inflammation. The identification of the FoxP3+CD69+ Treg subset paves the way toward the development of new therapeutic strategies to control immune homeostasis and autoimmunity. äMaintenance of immune tolerance by Foxp3+ regulatory T cells requires (epmc).pdf DeepDyve Pubget Overpricing