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2015 ; 10
(10
): e0140121
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Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in
Models of Acute Kidney Injury
#MMPMID26509261
Hattori Y
; Kim H
; Tsuboi N
; Yamamoto A
; Akiyama S
; Shi Y
; Katsuno T
; Kosugi T
; Ueda M
; Matsuo S
; Maruyama S
PLoS One
2015[]; 10
(10
): e0140121
PMID26509261
show ga
BACKGROUND: Acute kidney injury (AKI) is a critical condition associated with
high mortality. However, the available treatments for AKI are limited. Stem cells
from human exfoliated deciduous teeth (SHED) have recently gained attention as a
novel source of stem cells. The purpose of this study was to clarify whether SHED
have a therapeutic effect on AKI induced by ischemia-reperfusion injury. METHODS:
The left renal artery and vein of the mice were clamped for 20 min to induce
ischemia. SHED, bone marrow derived mesenchymal stem cells (BMMSC) or
phosphate-buffered saline (control) were administered into the subrenal capsule.
To confirm the potency of SHED in vitro, H2O2 stimulation assays and scratch
assays were performed. RESULTS: The serum creatinine and blood urea nitrogen
levels of the SHED group were significantly lower than those of the control
group, while BMMSC showed no therapeutic effect. Infiltration of macrophages and
neutrophils in the kidney was significantly attenuated in mice treated with SHED.
Cytokine levels (MIP-2, IL-1?, and MCP-1) in mice kidneys were significantly
reduced in the SHED group. In in vitro experiments, SHED significantly decreased
MCP-1 secretion in tubular epithelial cells (TEC) stimulated with H2O2. In
addition, SHED promoted wound healing in the scratch assays, which was blunted by
anti-HGF antibodies. DISCUSSION: SHED attenuated the levels of inflammatory
cytokines and improved kidney function in AKI induced by IRI. SHED secreted
factors reduced MCP-1 and increased HGF expression, which promoted wound healing.
These results suggest that SHED might provide a novel stem cell resource, which
can be applied for the treatment of ischemic kidney injury.
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