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10.1080/08916930400010611 http://scihub22266oqcxt.onion/10.1080/08916930400010611 C4624307!4624307!15621569     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autoimmunity 2004 ; 37 (ä): 431-43 Nephropedia Template TP {{tp|p=15621569|t=2004. Ongoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells: Analysis of Switch Regulatory Regions |pdf=|usr=}}{{15621569}} gab.com Text Ongoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells: Analysis of Switch Regulatory Regions JO: Autoimmunity http://www.kidney.de/pget.php?&tw=1&pmid=15621569 #FOAvip Inflammation and tissue damage in systemic lupus erythematosus (SLE) are mediated by class-switched autoantibodies reactive with nucleic acids, nucleic acid-binding proteins, phospholipids and other self-antigens. While some healthy individuals produce IgM antibodies with specificities similar to those of lupus patients, immunoglobulin class switching to mature downstream isotypes appears to be required for the generation of pathogenic autoantibodies. To characterize the cellular and molecular basis of pathogenic autoantibody production in SLE, we studied the capacity of peripheral blood B cells of naïve phenotype from patients with SLE, rheumatoid arthritis (RA) or healthy control subjects to spontaneously switch to IgG and IgA. In addition, we determined the DNA sequences of the upstream evolutionary conserved sequence (ECS)-I? promoter regulatory regions that control germline IH-CH transcription and class switch DNA recombination (CSR) to IgG1, IgG2 and IgG4. IgM+IgD+ B cells from patients with SLE, but not those from RA or healthy control subjects, underwent spontaneous CSR, as assessed by expression of germline I?1-C?1, I?2-C?2, I?3-C?3, I?4-C?4 and I?1-C?1 transcripts, mature (switched) VHDJH-C?1, VHDJH-C?2, VHDJH-C?3 and VHDJH-C?1 transcripts and secreted IgG and IgA. Although polymorphic DNA sequences were identified in the ECS-I?1, ECS-I?2 and ECS-I?4 promoter regions, the transcription factor-binding sites that mediate germline I?-C? transcription were conserved in patients and controls. However, distinct patterns of nuclear protein binding to an ECS-I? promoter sequence that contains both positive and negative regulatory elements were observed in SLE patients and controls. These results support a role for exogenous signals, such as through CD40 ligation, rather than altered genomic sequence, in the increased production of class switched autoantibodies in SLE. Twit Text FOAVip Ongoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells: Analysis of Switch Regulatory Regions ????Autoimmunity http://www.kidney.de/pget.php?&tw=1&pmid=15621569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15621569 #FOAvip English Wikipedia <ref>{{Cite pmid|15621569}}</ref> Ongoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells: Analysis of Switch Regulatory Regions #MMPMID15621569 LIU S; CERUTTI A; CASALI P; CROW MK Autoimmunity 2004[Sep]; 37 (ä): 431-43 PMID15621569show ga Inflammation and tissue damage in systemic lupus erythematosus (SLE) are mediated by class-switched autoantibodies reactive with nucleic acids, nucleic acid-binding proteins, phospholipids and other self-antigens. While some healthy individuals produce IgM antibodies with specificities similar to those of lupus patients, immunoglobulin class switching to mature downstream isotypes appears to be required for the generation of pathogenic autoantibodies. To characterize the cellular and molecular basis of pathogenic autoantibody production in SLE, we studied the capacity of peripheral blood B cells of naïve phenotype from patients with SLE, rheumatoid arthritis (RA) or healthy control subjects to spontaneously switch to IgG and IgA. In addition, we determined the DNA sequences of the upstream evolutionary conserved sequence (ECS)-I? promoter regulatory regions that control germline IH-CH transcription and class switch DNA recombination (CSR) to IgG1, IgG2 and IgG4. IgM+IgD+ B cells from patients with SLE, but not those from RA or healthy control subjects, underwent spontaneous CSR, as assessed by expression of germline I?1-C?1, I?2-C?2, I?3-C?3, I?4-C?4 and I?1-C?1 transcripts, mature (switched) VHDJH-C?1, VHDJH-C?2, VHDJH-C?3 and VHDJH-C?1 transcripts and secreted IgG and IgA. Although polymorphic DNA sequences were identified in the ECS-I?1, ECS-I?2 and ECS-I?4 promoter regions, the transcription factor-binding sites that mediate germline I?-C? transcription were conserved in patients and controls. However, distinct patterns of nuclear protein binding to an ECS-I? promoter sequence that contains both positive and negative regulatory elements were observed in SLE patients and controls. These results support a role for exogenous signals, such as through CD40 ligation, rather than altered genomic sequence, in the increased production of class switched autoantibodies in SLE. äOngoing Immunoglobulin Class Switch DNA Recombination in Lupus B Cells(epmc).pdf DeepDyve Pubget Overpricing